Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/52286
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Thrombophilias and adverse pregnancy outcome - A confounded problem! |
Author: | Kist, W. Janssen, N. Kalk, J. Hague, W. Dekker, G. de Vries, J. |
Citation: | Thrombosis and Haemostasis, 2008; 99(1):77-85 |
Publisher: | Schattauer GMBH-Verlag Medizin Naturwissenschaften |
Issue Date: | 2008 |
ISSN: | 0340-6245 2567-689X |
Statement of Responsibility: | Willem J. Kist, Nard G. Janssen, Jakoba J. Kalk, William M. Hague, Gustaaf A. Dekker, Johanna I. P. de Vries |
Abstract: | It was the objective of this study to analyse the influence of confounders, such as ethnicity,severity of illness and method of testing, in articles concerning the still moot relationship of thrombophilias to adverse pregnancy outcome (APO). Relevant casecontrol studies were identified using Medline and EMBASE databases between 1966 and 2006. Search terms were recurrent fetal loss, intrauterine fetal death, preeclampsia, HELLP-syndrome, eclampsia, fetal growth restriction, abruptio placentae, combined with maternal thrombophilias. Data was extracted from the articles per subgroup ofAPO regardless of confounder. These subgroups were tested if they fulfilled the heterogeneity testing criterion (I2 > 35%) to weigh the influence of the confounder. Confounders were selected and examined with Mantel- Haenszel method. Increased thrombophilia prevalence was confirmed in most adverse pregnancy outcomes. Ethnicity, genetic testing only and severity of illness were confounders in the various forms of APO. Stronger relationships between factor V Leiden and severity of disease were found in 2nd and 3rd trimester than 1st trimester recurrent fetal loss, in preeclampsia with: blood pressure ≥160/110 mmHg than ≥140/90 mmHg; proteinuria ≥5 grams per day than < 5 grams; onset before than after 28 weeks, in fetal growth restriction <3rd percentile than <5th, than <10th, and in earlier occurrence of abruptio placentae than 3rd trimester. In conclusion, reports on the prevalence of maternal thrombophilias and APO are influenced by various confounders, which are not always appropriately analysed.The differences we have identified reflect the differential impact of these confounders. These data emphasise the importance of more uniform research. |
Keywords: | Humans Abortion, Habitual Fetal Growth Retardation Abruptio Placentae Pregnancy Complications, Hematologic Thrombophilia Genetic Predisposition to Disease Pregnancy Outcome Severity of Illness Index Prevalence Risk Factors Case-Control Studies Epidemiologic Research Design Reproducibility of Results Pregnancy Genotype Phenotype Female Genetic Testing Confounding Factors, Epidemiologic |
DOI: | 10.1160/TH07-05-0373 |
Published version: | http://dx.doi.org/10.1160/th07-05-0373 |
Appears in Collections: | Aurora harvest 5 Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.