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Type: Journal article
Title: Comparable outcomes in nonsecretory and secretory multiple myeloma after autologous stem cell transplantation
Author: Kumar, S.
Perez, W.
Zhang, M.
Ballen, K.
Bashey, A.
To, L.
Bredeson, C.
Cairo, M.
Elfenbein, G.
Freytes, C.
Gale, R.
Gibson, J.
Kyle, R.
Lacy, M.
Lazarus, H.
McCarthy, P.
Milone, G.
Moreb, J.
Pavlovsky, S.
Reece, D.
et al.
Citation: Biology of Blood and Marrow Transplantation, 2008; 14(10):1134-1140
Publisher: Carden Jennings Publ Co Ltd
Issue Date: 2008
ISSN: 1083-8791
Statement of
Shaji Kumar, Waleska S. Pérez, Mei-Jie Zhang, Karen Ballen, Asad Bashey, L. Bik To, Christopher N. Bredeson, Mitchell S. Cairo, Gerald J. Elfenbein, César O. Freytes, Robert Peter Gale, John Gibson, Robert A. Kyle, Martha Q. Lacy, Hillard M. Lazarus, Philip L. McCarthy, Gustavo A. Milone, Jan S. Moreb, Santiago Pavlovsky, Donna E. Reece, David H. Vesole, Peter H. Wiernik and Parameswaran Hari
Abstract: Nonsecretory myeloma (NSM) accounts for <5% of cases of multiple myeloma (MM). The outcome of these patients following autologous stem cell transplantation (ASCT) has not been evaluated in clinical trials. We compared the outcomes after ASCT for patients with NSM reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) between 1989 and 2003, to a matched group of 438 patients (4 controls for each patient) with secretory myeloma (SM). The patients were matched using propensity scores calculated using age, Durie-Salmon stage, sensitivity to pretransplant therapy, time from diagnosis to transplant, and year of transplant. Disease characteristics were similar in both groups at diagnosis and at transplant except higher risk of anemia, hypoalbuminemia, and marrow plasmacytosis (in SM) and plasmacytoma (more in NSM). Cumulative incidence of treatment-related mortality (TRM), relapse, progression-free survival (PFS), and overall survival (OS) were similar between the groups. In multivariate analysis, based on a Cox model stratified on matched pairs and adjusted for covariates not considered in the propensity score, we found no difference in outcome between the NSM and SM groups. In this large cohort of patients undergoing ASCT, we found no difference in outcomes of patients with NSM compared to those with SM.
Keywords: Humans
Multiple Myeloma
Treatment Outcome
Hematopoietic Stem Cell Transplantation
Transplantation, Autologous
Analysis of Variance
Survival Analysis
Retrospective Studies
Middle Aged
Description: Copyright © 2008 American Society for Blood and Marrow Transplantation Published by Elsevier Inc.
DOI: 10.1016/j.bbmt.2008.07.011
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Appears in Collections:Aurora harvest
Pathology publications

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