Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/53671
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dc.contributor.authorSevak, R.en
dc.contributor.authorKoek, W.en
dc.contributor.authorDaws, L.en
dc.contributor.authorOwens, W.en
dc.contributor.authorGalli, A.en
dc.contributor.authorFrance, C.en
dc.date.issued2008en
dc.identifier.citationEuropean Journal of Pharmacology, 2008; 581(1-2):105-112en
dc.identifier.issn0014-2999en
dc.identifier.urihttp://hdl.handle.net/2440/53671-
dc.description.abstractExperimentally-induced diabetes can modify the behavioral and neurochemical effects of drugs acting on dopamine systems, possibly through insulin-related regulation of dopamine transporter activity. In this study, several behavioral procedures were used to examine possible changes in sensitivity to amphetamine and other drugs in rats rendered diabetic by a single injection of streptozotocin. Conditioned place preference developed to food (Froot Loops) in both control and diabetic rats, demonstrating that conditioned place preference with tactile stimuli can occur in streptozotocin-treated rats. Baseline locomotion was lower in streptozotocin-treated as compared to control rats, although amphetamine significantly increased locomotion in all rats. Conditioned place preference developed to amphetamine regardless of whether rats had received streptozotocin or saline. A second study compared the potency of drugs to decrease lever pressing maintained by food, before and after streptozotocin treatment. Gamma-hydroxybutyrate and amphetamine were less potent after streptozotocin while the potency of raclopride, quinpirole, ketamine, haloperidol and cocaine was not significantly changed by streptozotocin. While markedly affecting locomotion, body weight and blood glucose, streptozotocin only modestly affected sensitivity to the behavioral effects of amphetamine and other drugs; these results fail to confirm previous reports of decreased behavioral actions of stimulants in diabetic rats.en
dc.description.statementofresponsibilityRajkumar J. Sevak, Wouter Koek, Lynette C. Daws, William Anthony Owens, Aurelio Galli and Charles P. Franceen
dc.language.isoenen
dc.publisherElsevier Science BVen
dc.titleBehavioral effects of amphetamine in streptozotocin-treated ratsen
dc.typeJournal articleen
dc.identifier.rmid0020084910en
dc.identifier.doi10.1016/j.ejphar.2007.11.047en
dc.identifier.pubid40442-
pubs.library.collectionPharmacology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Pharmacology publications

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