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https://hdl.handle.net/2440/55672
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Type: | Journal article |
Title: | Microvascular blood flow, clinical illness severity and cardiovascular function in the preterm infant |
Author: | Stark, M. Clifton, V. Wright, I. |
Citation: | Archives of Disease in Childhood: Fetal and Neonatal Edition, 2008; 93(4):F271-F274 |
Publisher: | B M J Publishing Group |
Issue Date: | 2008 |
ISSN: | 1359-2998 1468-2052 |
Statement of Responsibility: | M. J. Stark, V. L. Clifton and I. M. R. Wright |
Abstract: | Objectives: To characterise the relationships between peripheral microvascular blood flow and measures of physiological and cardiovascular function in preterm infants in the immediate newborn period. Design: Prospective observational cohort study. Setting: Tertiary neonatal intensive care unit, New South Wales, Australia. Patients: Ninety-six preterm neonates (24–36 weeks’ gestation) admitted to the neonatal intensive care unit. Main outcome measure: Relationship between laser Doppler-derived basal microvascular blood flow, functional echocardiographic measurements of cardiovascular status, mean arterial blood pressure and clinical illness severity at 24, 72 and 120 h of age. Results: At 24 h of age, multiple linear regression revealed a significant positive relationship, independent of gestational age, between baseline microvascular blood flow and clinical risk index for babies (CRIB II) score (r2 = 0.442). Microvascular blood flow was inversely related to mean arterial blood pressure (r2 = −0.563), and correlated positively with left ventricular output (r2 = 0.435). Microvascular blood flow continued to exhibit a significant inverse relationship with mean arterial blood pressure (r2 = −0.4) at 72 h of age, but by 120 h no significant relationships were evident. Conclusions: This is the first study to show that baseline microvascular blood flow in premature infants exhibits significant relationships with clinical illness severity and cardiovascular function in the immediate postnatal period. The effects of temporal and functional changes in the microvasculature on cardiovascular adaptation warrant further detailed study. |
Keywords: | Cardiovascular System Arteries Microcirculation Humans Ultrasonography Laser-Doppler Flowmetry Severity of Illness Index Cohort Studies Prospective Studies Blood Pressure Infant, Newborn Infant, Premature Female Male |
Description: | Copyright © 2008 by the BMJ Publishing Group Ltd. |
DOI: | 10.1136/adc.2007.123539 |
Published version: | http://dx.doi.org/10.1136/adc.2007.123539 |
Appears in Collections: | Aurora harvest 5 Obstetrics and Gynaecology publications |
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