Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/56666
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dc.contributor.authorValenzuela, A.en
dc.contributor.authorArchibald, C.en
dc.contributor.authorFleming, B.en
dc.contributor.authorOng, L.en
dc.contributor.authorO'Donnell, B.en
dc.contributor.authorCrompton, J.en
dc.contributor.authorSelva-Nayagam, D.en
dc.contributor.authorMcNab, A.en
dc.contributor.authorSullivan, T.en
dc.date.issued2009en
dc.identifier.citationOrbit, 2009; 28(2-3):153-159en
dc.identifier.issn0167-6830en
dc.identifier.issn1744-5108en
dc.identifier.urihttp://hdl.handle.net/2440/56666-
dc.descriptionCopyright © Informa Healthcare USA, Inc.en
dc.description.abstractPurpose: To review the clinical features, treatment, outcome and survival of metastatic tumors of the orbit. Materials and Methods: Retrospective, non-comparative, chart review of 80 patients with orbital metastasis treated in four tertiary orbital centres in Australia. Results: The study included 80 patients of which, 44 were male with a mean age of 60 years. Orbital involvement commonly presented late in a multisystemic disease; however, the orbit was the first presentation in 15% of the cases. Diplopia (48%), pain (42%), and visual loss (30%) were the commonest symptoms at presentation; whereas proptosis (63%), strabismus (62%), and visual loss (41%) were the most frequent clinical signs. Computed tomography commonly showed a solid enhancing mass (42 cases) located within the orbital fat (43%), or enlarging an extraocular muscle (28%). Breast carcinoma (29%), melanoma (20%), and prostatic cancer (13%) were the most frequent histological types. Treatment was often multi-disciplinary and modalities included radiotherapy, chemotherapy, hormone therapy, surgery, and immunotherapy. Survival was limited to 1.5 years after diagnosis independent of the histological type, with 29% of patients alive after 17 months follow-up. Conclusions: A high index of suspicion and appropriate intervention with histological diagnosis can help in the management and quality of life in patients with metastatic orbital disease. Overall survival is limited and we encountered statistical limitations proving differences in the survival based on the sub-type of primary tumour involved. Metastatic orbital melanoma presented a higher incidence when compared with previous studies, probably due to the increase frequency of skin found in the Australian population.en
dc.description.statementofresponsibilityAlejandra A. Valenzuela, Curtis W. Archibald, Ben Fleming, Lorraine Ong, Brett O'Donnell, John Crompton, Dinesh Selva, Alan A. McNab and Timothy J. Sullivanen
dc.language.isoenen
dc.publisherTaylor & Francis The Netherlandsen
dc.subjectorbital tumors; metastasis; histopathology; managementen
dc.titleOrbital metastasis: Clinical features, management and outcomeen
dc.typeJournal articleen
dc.identifier.rmid0020093295en
dc.identifier.doi10.1080/01676830902897470en
dc.identifier.pubid37117-
pubs.library.collectionOpthalmology & Visual Sciences publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidSelva-Nayagam, D. [0000-0002-2169-5417]en
Appears in Collections:Opthalmology & Visual Sciences publications

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