Adelaide Research & Scholarship
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https://hdl.handle.net/2440/57096
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| Type: | Journal article |
| Title: | A Peptide Antagonist of the TLR4-MD2 Interaction |
| Author: | Slivka, P. Shridhar, M. Lee, G. Sammond, D. Hutchinson, M. Martinko, A. Buchanan, M. Sholar, P. Kearney, J. Harrison, J. Watkins, L. Yin, H. |
| Citation: | ChemBioChem: a European journal of chemical biology, 2009; 10(4):645-649 |
| Publisher: | Wiley-VCH Verlag GMBH |
| Issue Date: | 2009 |
| ISSN: | 1439-4227 1439-7633 |
| Statement of Responsibility: | Peter F. Slivka, Mitesh Shridhar, Gui-in Lee, Deanne W. Sammond, Mark R. Hutchinson, Alexander J. Martinko, Madison M. Buchanan, Page W. Sholar, Jeffrey J. Kearney, Jacqueline A. Harrison, Linda R. Watkins and Hang Yin |
| Abstract: | Toll-like receptors are an integral part of innate immunity in the central nervous system (CNS); they orchestrate a robust defense in response to both exogenous and endogenous danger signals. Recently, toll-like receptor 4 (TLR4) has emerged as a therapeutic target for the treatment of CNS-related diseases such as sepsis and chronic pain. We herein report a chemical biology approach by using a rationally designed peptide inhibitor to disrupt the TLR4-MD2 association, thereby blocking TLR4 signaling. |
| Keywords: | Cell Line Animals Mice Peptides Adaptor Proteins, Signal Transducing Computational Biology Protein Conformation Protein Binding Models, Molecular Toll-Like Receptor 4 Lymphocyte Antigen 96 |
| DOI: | 10.1002/cbic.200800769 |
| Published version: | http://dx.doi.org/10.1002/cbic.200800769 |
| Appears in Collections: | Aurora harvest 5 Pharmacology publications |
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