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Type: Journal article
Title: A Peptide Antagonist of the TLR4-MD2 Interaction
Author: Slivka, P.
Shridhar, M.
Lee, G.
Sammond, D.
Hutchinson, M.
Martinko, A.
Buchanan, M.
Sholar, P.
Kearney, J.
Harrison, J.
Watkins, L.
Yin, H.
Citation: ChemBioChem: a European journal of chemical biology, 2009; 10(4):645-649
Publisher: Wiley-VCH Verlag GMBH
Issue Date: 2009
ISSN: 1439-4227
Statement of
Peter F. Slivka, Mitesh Shridhar, Gui-in Lee, Deanne W. Sammond, Mark R. Hutchinson, Alexander J. Martinko, Madison M. Buchanan, Page W. Sholar, Jeffrey J. Kearney, Jacqueline A. Harrison, Linda R. Watkins and Hang Yin
Abstract: Toll-like receptors are an integral part of innate immunity in the central nervous system (CNS); they orchestrate a robust defense in response to both exogenous and endogenous danger signals. Recently, toll-like receptor 4 (TLR4) has emerged as a therapeutic target for the treatment of CNS-related diseases such as sepsis and chronic pain. We herein report a chemical biology approach by using a rationally designed peptide inhibitor to disrupt the TLR4-MD2 association, thereby blocking TLR4 signaling.
Keywords: Cell Line
Adaptor Proteins, Signal Transducing
Computational Biology
Protein Conformation
Protein Binding
Models, Molecular
Toll-Like Receptor 4
Lymphocyte Antigen 96
DOI: 10.1002/cbic.200800769
Appears in Collections:Aurora harvest 5
Pharmacology publications

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