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Type: Journal article
Title: Magnesium attenuates persistent functional deficits following diffuse traumatic brain injury in rats
Author: Vink, R.
O'Connor, C.
Nimmo, A.
Heath, D.
Citation: Neuroscience Letters, 2003; 336(1):41-44
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2003
ISSN: 0304-3940
Statement of
Robert Vink, Christine A. O'Connor, Alan J. Nimmo and Deanne L. Heath
Abstract: Although a number of studies have demonstrated that magnesium improves acute motor and cognitive outcome after traumatic brain injury, others have failed to show positive effects on cognitive outcome and none have examined persistent functional deficits. The present study shows that severe impact-acceleration induced, diffuse traumatic brain injury in rats produced profound motor and cognitive deficits that persisted for at least 4 weeks after trauma. Intravenous administration of magnesium sulfate (250 micromoles/kg) at 30 min after injury significantly improved rotarod (sensorimotor) and open field (stress/anxiety) performance, and led to a faster rate of recovery in the Barnes maze (learning). We conclude that posttraumatic magnesium administration attenuates long-term motor and cognitive deficits after traumatic brain injury, and that this improvement may include some reduction of post-traumatic stress and anxiety.
Keywords: Animals; Rats; Rats, Sprague-Dawley; Brain Injuries; Disease Models, Animal; Magnesium Sulfate; Motor Activity; Cognition; Maze Learning; Time Factors; Male
Description: Copyright © 2002 Elsevier Science Ireland Ltd. All rights reserved.
RMID: 0020030846
DOI: 10.1016/S0304-3940(02)01244-2
Appears in Collections:Pathology publications

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