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Type: Journal article
Title: Genetic influences on the pharmacokinetics of orally and intravenously administered Digoxin as exhibited by monozygotic twins
Author: Birkenfeld, A.
Jordan, J.
Hofmann, U.
Busjahn, A.
Franke, G.
Kruger, N.
Igel, S.
Murdter, T.
Drescher, S.
Shi, S.
Engeli, S.
Schwab, M.
Eichelbaum, M.
Luft, F.
Fromm, M.
Citation: Clinical Pharmacology & Therapeutics, 2009; 86(6):605-608
Publisher: Mosby Inc
Issue Date: 2009
ISSN: 0009-9236
Statement of
A. L. Birkenfeld, J. Jordan, U. Hofmann, A. Busjahn, G. Franke, N. Krüger, S. Igel, T. Mürdter, S. Drescher, S. Shi, S. Engeli, M. Schwab, M. Eichelbaum, F. C. Luft and M. F. Fromm
Abstract: The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P-glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics.
Keywords: Humans; Deuterium; Digoxin; P-Glycoprotein; Administration, Oral; Infusions, Intravenous; Registries; Pilot Projects; Twins, Monozygotic; Genotype; Phenotype; Adult; Female; Male; Genetic Variation; Young Adult
Rights: Copyright © 2009, Nature Publishing Group
RMID: 0020096554
DOI: 10.1038/clpt.2009.170
Appears in Collections:Pharmacology publications

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