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https://hdl.handle.net/2440/58387
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dc.contributor.author | Birkenfeld, A. | - |
dc.contributor.author | Jordan, J. | - |
dc.contributor.author | Hofmann, U. | - |
dc.contributor.author | Busjahn, A. | - |
dc.contributor.author | Franke, G. | - |
dc.contributor.author | Kruger, N. | - |
dc.contributor.author | Igel, S. | - |
dc.contributor.author | Murdter, T. | - |
dc.contributor.author | Drescher, S. | - |
dc.contributor.author | Shi, S. | - |
dc.contributor.author | Engeli, S. | - |
dc.contributor.author | Schwab, M. | - |
dc.contributor.author | Eichelbaum, M. | - |
dc.contributor.author | Luft, F. | - |
dc.contributor.author | Fromm, M. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Clinical Pharmacology and Therapeutics, 2009; 86(6):605-608 | - |
dc.identifier.issn | 0009-9236 | - |
dc.identifier.issn | 1532-6535 | - |
dc.identifier.uri | http://hdl.handle.net/2440/58387 | - |
dc.description.abstract | The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P-glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics. | - |
dc.description.statementofresponsibility | A. L. Birkenfeld, J. Jordan, U. Hofmann, A. Busjahn, G. Franke, N. Krüger, S. Igel, T. Mürdter, S. Drescher, S. Shi, S. Engeli, M. Schwab, M. Eichelbaum, F. C. Luft and M. F. Fromm | - |
dc.language.iso | en | - |
dc.publisher | Mosby Inc | - |
dc.rights | Copyright © 2009, Nature Publishing Group | - |
dc.source.uri | http://dx.doi.org/10.1038/clpt.2009.170 | - |
dc.subject | Humans | - |
dc.subject | Deuterium | - |
dc.subject | Digoxin | - |
dc.subject | Administration, Oral | - |
dc.subject | Infusions, Intravenous | - |
dc.subject | Registries | - |
dc.subject | Pilot Projects | - |
dc.subject | Twins, Monozygotic | - |
dc.subject | Genotype | - |
dc.subject | Phenotype | - |
dc.subject | Adult | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Genetic Variation | - |
dc.subject | Young Adult | - |
dc.subject | ATP Binding Cassette Transporter, Subfamily B | - |
dc.subject | ATP Binding Cassette Transporter, Subfamily B, Member 1 | - |
dc.title | Genetic influences on the pharmacokinetics of orally and intravenously administered Digoxin as exhibited by monozygotic twins | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/clpt.2009.170 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Pharmacology publications |
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