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Issue Date
Title
Author(s)
2013
STAT5 is a critical component of the time-dependent sensitivity of CML cells to TKI treatment in a BCR-ABL-dependent, but JAK2-independent manner
Schafranek, L.
;
Nievergall, E.
;
Powell, J.
;
Hiwase, D.
;
White, D.
;
Hughes, T.
;
Leclercq, T.
2010
Selective escalation of imatinib therapy and early switching to nilotinib in de novo chronic phase CML patients: interim results from the TIDELL-II trial
Yeung, D.
;
Osborn, M.
;
White, D.
;
Branford, S.
;
Haswell, L.
;
Slader, C.
;
Issa, S.
;
Hiwase, D.
;
Hertzberg, M.
;
Schwarer, A.
;
Filshie, R.
;
Arthur, C.
;
Kwan, Y.
;
Forsyth, C.
;
Ross, D.
;
Mills, A.
;
Grigg, A.
;
Hughes, T.
;
Annual Meeting of the American Society of Hematology (52nd : 2010 : Orlando, Fl.)
2016
TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy
Nievergall, E.
;
Reynolds, J.
;
Kok, C.
;
Watkins, D.
;
Biondo, M.
;
Busfield, S.
;
Vairo, G.
;
Fuller, K.
;
Erber, W.
;
Sadras, T.
;
Grose, R.
;
Yeung, D.
;
Lopez, A.
;
Hiwase, D.
;
Hughes, T.
;
White, D.
2014
Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells
Nievergall, E.
;
Ramshaw, H.
;
Yong, A.
;
Biondo, M.
;
Busfield, S.
;
Vairo, G.
;
Lopez, A.
;
Hughes, T.
;
White, D.
;
Hiwase, D.
2013
Proton pump inhibitors significantly increase the intracellular concentration of nilotinib, but not imatinib in target CML cells
White, D.
;
Eadie, L.
;
Saunders, V.
;
Hiwase, D.
;
Hughes, T.
2010
Nilotinib-mediated inhibition of ABCB1 increases intracellular concentration of dasatinib in CML cells: implications for combination TKI therapy
Hiwase, D.
;
White, D.
;
Zrim, S.
;
Saunders, V.
;
Vaz de Melo, J.
;
Hughes, T.
2010
Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors
Hiwase, D.
;
White, D.
;
Powell, J.
;
Saunders, V.
;
Zrim, S.
;
Frede, A.
;
Guthridge, M.
;
Lopez, A.
;
D'Andrea, R.
;
To, L.
;
Vaz de Melo, J.
;
Kumar, S.
;
Hughes, T.
2008
Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications
Hiwase, D.
;
Saunders, V.
;
Hewett, D.
;
Frede, A.
;
Zrim, S.
;
Dang, P.
;
Eadie, L.
;
To, L.
;
Vaz de Melo, J.
;
Kumar, S.
;
Hughes, T.
;
White, D.
2013
Dasatinib targets chronic myeloid leukemia-CD34⁺ progenitors as effectively as it targets mature cells
Hiwase, D.
;
Saunders, V.
;
Nievergall, E.
;
Ross, D.
;
White, D.
;
Hughes, T.
2015
Sustained inhibition of STAT5, but not JAK2, is essential for TKI-induced cell death in chronic myeloid leukemia
Schafranek, L.
;
Nievergall, E.
;
Powell, J.
;
Hiwase, D.
;
Leclercq, T.
;
Hughes, T.
;
White, D.
Discover
Author
5
Nievergall, E.
5
Saunders, V.
3
Lopez, A.
3
Powell, J.
3
Vaz de Melo, J.
3
Zrim, S.
2
Biondo, M.
2
Busfield, S.
2
Eadie, L.
2
Frede, A.
.
next >
Subject
7
Leukemia, Myelogenous, Chronic, B...
6
Humans
4
Protein Kinase Inhibitors
4
Pyrimidines
3
Antigens, CD34
3
ATP Binding Cassette Transporter,...
3
ATP Binding Cassette Transporter,...
3
Dasatinib
3
K562 Cells
3
Thiazoles
.
next >
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2013
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2010
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2008