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PreviewIssue DateTitleAuthor(s)
2019OBI-3424, a novel AKR1c3-activated prodrug, exhibits potent efficacy against preclinical models of T-ALLEvans, K.; Duan, J.X.; Pritchard, T.; Jones, C.D.; McDermott, L.; Gu, Z.; Toscan, C.E.; El-Zein, N.; Mayoh, C.; Erickson, S.W.; Guo, Y.; Meng, F.; Jung, D.; Rathi, K.S.; Roberts, K.G.; Mullighan, C.G.; Shia, C.S.; Pearce, T.; Teicher, B.A.; Smith, M.A.; et al.
2020The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1Carmichael, C.L.; Wang, J.; Nguyen, T.; Kolawole, O.; Benyoucef, A.; De Mazière, C.; Milne, A.R.; Samuel, S.; Gillinder, K.; Hediyeh-Zadeh, S.; Vo, A.N.Q.; Huang, Y.; Knezevic, K.; McInnes, W.R.L.; Shields, B.J.; Mitchell, H.; Ritchie, M.E.; Lammens, T.; Lintermans, B.; Van Vlierberghe, P.; et al.
2019A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancerWarren, A.; Massie, C.; Watt, K.; Luko, K.; Orafidiya, F.; Selth, L.; Mohammed, H.; Chohan, B.; Menon, S.; Baridi, A.; Zhao, W.; Escriu, C.; Pungsrinont, T.; D Santos, C.; Yang, X.; Taylor, C.; Qureshi, A.; Zecchini, V.; Shaw, G.; Dehm, S.; et al.
2021Targeting DNA Damage Response and Replication Stress in Pancreatic CancerDreyer, S.B.; Upstill-Goddard, R.; Paulus-Hock, V.; Paris, C.; Lampraki, E.M.; Dray, E.; Serrels, B.; Caligiuri, G.; Rebus, S.; Plenker, D.; Galluzzo, Z.; Brunton, H.; Cunningham, R.; Tesson, M.; Nourse, C.; Bailey, U.M.; Jones, M.; Moran-Jones, K.; Wright, D.W.; Duthie, F.; et al.
2019Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancerWatt, M.J.; Clark, A.K.; Selth, L.A.; Haynes, V.R.; Lister, N.; Rebello, R.; Porter, L.H.; Niranjan, B.; Whitby, S.T.; Lo, J.; Huang, C.; Schittenhelm, R.B.; Anderson, K.E.; Furic, L.; Wijayaratne, P.R.; Matzaris, M.; Montgomery, M.K.; Papargiris, M.; Norden, S.; Febbraio, M.; et al.
2020Endonuclease FEN1 coregulates ERα activity and provides a novel drug interface in tamoxifen resistant breast cancerFlach, K.D.; Periyasamy, M.; Jadhav, A.; Dorjsuren, D.; Siefert, J.C.; Hickey, T.E.; Opdam, M.; Patel, H.; Canisius, S.; Wilson, D.M.; Donaldson Collier, M.; Prekovic, S.; Nieuwland, M.; Kluin, R.J.; Zakharov, A.V.; Wesseling, J.; Wessels, L.F.A.; Linn, S.C.; Tilley, W.D.; Simeonov, A.; et al.
2019Extracellular fatty acids are the major contributor to lipid synthesis in prostate cancerBalaban, S.; Nassar, Z.D.; Zhang, A.Y.; Hosseini-Beheshti, E.; Centenera, M.M.; Schreuder, M.; Lin, H.M.; Aishah, A.; Varney, B.; Liu-Fu, F.; Lee, L.S.; Nagarajan, S.R.; Shearer, R.F.; Hardie, R.A.; Raftopulos, N.L.; Kakani, M.S.; Saunders, D.N.; Holst, J.; Horvath, L.G.; Butler, L.M.; et al.
2015Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer riskPainter, J.; O'Mara, T.; Batra, J.; Cheng, T.; Lose, F.; Dennis, J.; Michailidou, K.; Tyrer, J.; Ahmed, S.; Ferguson, K.; Healey, C.; Kaufmann, S.; Hillman, K.; Walpole, C.; Moya, L.; Pollock, P.; Jones, A.; Howarth, K.; Martin, L.; Gorman, M.; et al.
2021Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanomaJacquelot, N.; Seillet, C.; Wang, M.; Pizzolla, A.; Liao, Y.; Hediyeh-Zadeh, S.; Grisaru-Tal, S.; Louis, C.; Huang, Q.; Schreuder, J.; Souza-Fonseca-Guimaraes, F.; de Graaf, C.A.; Thia, K.; Macdonald, S.; Camilleri, M.; Luong, K.; Zhang, S.; Chopin, M.; Molden-Hauer, T.; Nutt, S.L.; et al.
2021Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: guidance using optical window intravital FRET imagingFloerchinger, A.; Murphy, K.J.; Latham, S.L.; Warren, S.C.; McCulloch, A.T.; Lee, Y.-K.; Stoehr, J.; Mélénec, P.; Guaman, C.S.; Metcalf, X.L.; Lee, V.; Zaratzian, A.; Da Silva, A.; Tayao, M.; Rolo, S.; Phimmachanh, M.; Sultani, G.; McDonald, L.; Mason, S.M.; Ferrari, N.; et al.