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https://hdl.handle.net/2440/59384
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Type: | Journal article |
Title: | Long-term (5-year) antibody persistence following two- and three-dose regimens of a combined hepatitis A and B vaccine in children aged 1-11 years |
Author: | Marshall, H. Nolan, T. Diez-Domingo, J. Rombo, L. Sokal, E. Mares, J. Casanovas, J. Kuriyakose, S. Leyssen, M. Jacquet, J. |
Citation: | Vaccine, 2010; 28(27):4411-4415 |
Publisher: | Elsevier Sci Ltd |
Issue Date: | 2010 |
ISSN: | 0264-410X 1873-2518 |
Statement of Responsibility: | Helen Marshall, Terry Nolan, Javier Díez Domingo, Lars Rombo, Etienne M. Sokal, Josep Marès, Josep M. Casanovas, Sherine Kuriyakose, Maarten Leyssen and Jeanne-Marie Jacquet |
Abstract: | This study compared the long-term persistence of anti-hepatitis A (anti-HAV) and B (anti-HBs) antibodies, 5 years after vaccination of subjects aged 1-11 years with a combined hepatitis A and B vaccine either in a two-dose (0, 6 months, Adult formulation) or a three-dose (0, 1, 6 months, Paediatric formulation) schedule. At the end of the 5 years, all subjects (100%) in both groups continued to have anti-HAV antibodies > or =15mIU/mL, while 94-97% of subjects in both groups had anti-HBs antibody concentrations > or =10mIU/mL. Subjects with anti-HBs antibody concentration < or =10mIU/mL were administered a challenge dose of hepatitis B vaccine. All subjects mounted a vigorous immune response to the challenge indicating the presence of immunological memory to HBV. |
Keywords: | hepatitis paediatric combined |
Rights: | © 2010 Published by Elsevier Ltd. |
DOI: | 10.1016/j.vaccine.2010.04.040 |
Published version: | http://dx.doi.org/10.1016/j.vaccine.2010.04.040 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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