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Type: Journal article
Title: IGF1 and its binding proteins 3 and 1 are differentially associated with metabolic syndrome in older men
Author: Yeap, Bu B.
Chubb, S. A. Paul
Ho, Ken K. Y.
Setoh, Johnson W. S.
McCaul, Kieran Anthony
Norman, Paul E.
Jamrozik, Konrad
Flicker, Leon
Citation: European Journal of Endocrinology, 2010; 162(2):249-257
Publisher: Bio Scientifica Ltd
Issue Date: 2010
ISSN: 0804-4643
School/Discipline: School of Population Health and Clinical Practice : Public Health
Statement of
Bu B Yeap, S A Paul Chubb, Ken K Y Ho, Johnson W S Setoh, Kieran A McCaul, Paul E Norman, Konrad Jamrozik and Leon Flicker
Abstract: Objective: Circulating IGF1 declines with age, and reduced circulating IGF1 is associated with increased cardiovascular mortality in some but not all studies. The relationship between IGF-binding proteins 3 and 1 (IGFBP3 and IGFBP1) with risk of cardiovascular disease remains unclear. We sought to examine associations between IGF1, IGFBP3 and IGFBP1 with metabolic syndrome in older men. Design: Cross-sectional analysis of 3980 community-dwelling men aged 70 years. Methods: Morning plasma levels of IGF1, IGFBP3 and IGFBP1 were assayed. Metabolic syndrome was defined according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) criteria. Results: For IGF1 and IGFBP3, there was a U-shaped relationship, with middle quintiles possessing the lowest odds ratios (OR) for metabolic syndrome (reference Q1, Q3 IGF1: OR 0.74, 95% confidence intervals 0.57–0.96, Q3 IGFBP3: OR 0.67, 0.51–0.87). Increasing IGFBP1 was associated with reduced risk of metabolic syndrome with a dose–response gradient (reference Q1, OR for Q2 to Q5 IGFBP1: 0.56, 0.33, 0.22 and 0.12 respectively, P<0.001). IGF1 was associated with two, IGFBP1 with four and IGFBP3 with all five components of the metabolic syndrome. The ratio of IGF1/IGFBP3 was not associated with metabolic syndrome. Conclusions: In older men, both lower and higher IGF1 and IGFBP3 levels may be metabolically unfavourable. IGFBP1, as a marker of insulin sensitivity, is relevant in the assessment of metabolic syndrome, while the IGF1/IGFBP3 ratio is less informative. Longitudinal follow-up of this cohort would be needed to determine whether these distributions of IGF1, IGFBP3 and IGFBP1 predict incidence of cardiovascular events during male ageing.
Description: Copyright © 2010 by European Society of Endocrinology
RMID: 0020100216
DOI: 10.1530/EJE-09-0852
Appears in Collections:Public Health publications

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