Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/60468
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Changes in Doppler flow velocity waveforms and fetal size at 20 weeks gestation among cigarette smokers
Author: Kho, E.
North, R.
Chan, E.
Stone, P.
Dekker, G.
McCowan, L.
Citation: BJOG, 2009; 116(10):1300-1306
Publisher: Blackwell Publishing Ltd
Issue Date: 2009
ISSN: 1470-0328
1471-0528
Statement of
Responsibility: 
EM Kho, RA North, E Chan, PR Stone, GA Dekker, LME McCowan on behalf of the SCOPE consortium
Abstract: Objectives:  To compare umbilical and uterine artery Doppler waveforms and fetal size at 20 weeks between smokers and nonsmokers. Design:  Prospective cohort study. Setting:  Auckland, New Zealand and Adelaide, Australia. Population:  Nulliparous participants in the Screening for Pregnancy Endpoints (SCOPE) study. Methods:  Self-reported smoking status was determined at 15 ± 1 weeks’ gestation. At the 20 ± 1 week anatomy scan, uterine and umbilical Doppler resistance indices (RI) and fetal measurements were compared between smokers and nonsmokers. Main outcomes measures:  Umbilical and mean uterine artery Doppler RI values, abnormal umbilical and uterine Doppler (RI > 90th centile) and fetal biometry. Results:  Among the 2459 women, 248 (10%) were smokers. Smokers had higher umbilical RI [0.75 (SD 0.06) versus 0.73 (0.06), P < 0.0001] and mean uterine RI [0.59 (0.09) versus 0.56 (0.10), P < 0.0001]. They were twice as likely to have an abnormal umbilical Doppler at 20 weeks compared with nonsmokers [n = 35 (14.6%) versus n = 156 (7.2%), OR 2.21, 95% CI 1.49–3.27]. This effect remained significant after adjusting for age, ethnicity, marital status, employment and BMI (adjusted OR 1.62, 95% CI 1.03–2.54). Smokers were more likely to have an abnormal mean uterine RI [n = 33 (13.7%) versus n = 198 (9.2%), OR 1.57, 95% CI 1.06–2.33], but this association was not significant after adjusting for confounders. Fetuses of women who smoked had a small reduction in femur length and estimated weight compared with nonsmokers. Conclusions:  At 20 weeks’ gestation, women who smoke have higher umbilical artery RI, a surrogate measure for an abnormal placental villous vascular tree. This may contribute to later fetal growth restriction among smokers. Further research is needed to explore the clinical significance of these findings.
Keywords: Doppler; fetal growth; small for gestational age; smoking
Rights: © 2009 The Authors Journal compilation © RCOG 2009 BJOG An International Journal of Obstetrics and Gynaecology
RMID: 0020091675
DOI: 10.1111/j.1471-0528.2009.02266.x
Appears in Collections:Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.