Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/60551
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Is the international staging system superior to the Durie-Salmon staging system? A comparison in multiple myeloma patients undergoing autologous transplant |
Author: | Hari, P. Zhang, M. Roy, V. Perez, W. Bashey, A. To, L. Elfenbein, G. Freytes, C. Gale, R. Gibson, J. Kyle, R. Lazarus, H. McCarthy, P. Milone, G. Pavlovsky, S. Reece, D. Schiller, G. Vela-Ojeda, J. Weisdorf, D. Vesole, D. |
Citation: | Leukemia, 2009; 23(8):1528-1534 |
Publisher: | Nature Publishing Group |
Issue Date: | 2009 |
ISSN: | 0887-6924 1476-5551 |
Statement of Responsibility: | P. N. Hari, M-J Zhang, V. Roy, W. S. Pérez, A. Bashey, L. B. To, G. Elfenbein, C. O. Freytes, R. P. Gale, J. Gibson, R. A. Kyle, H. M. Lazarus, P. L. McCarthy, G. A. Milone, S. Pavlovsky, D. E. Reece, G. Schiller, J. Vela-Ojeda, D. Weisdorf and D. Vesole |
Abstract: | The international staging system (ISS) for multiple myeloma (MM) is a validated alternative to the Durie–Salmon staging system (DSS) for predicting survival at diagnosis. We compared these staging systems for predicting outcomes after upfront autologous stem cell transplantation by analyzing the outcomes of 729 patients between 1995 and 2002. With a median follow-up of 56 months, the univariate probabilities (95% CI) of non-relapse mortality (NRM), relapse, progression-free survival (PFS) and overall survival (OS) at 5 years were 7, 68, 25 and 52%, respectively. The median OS for stages I, II, III by DSS and ISS were 82, 68, 50 and 64, 68, 45 months, respectively. The concordance between the two staging systems was only 36%. Staging systems were formally compared using Cox models fit with DSS and ISS stages. The relative risks of PFS and OS were significantly different for stages I vs II and II vs III for DSS, but only for stages II vs III for ISS. Although both systems were predictive of PFS and OS, the DSS was superior in formal statistical comparison using Brier score. However, neither system was strongly predictive of outcomes, indicating the need for newer schemes incorporating other prognostic markers. |
Keywords: | myeloma autologous hematopoietic stem cell transplantation staging |
Rights: | © 2010 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. |
DOI: | 10.1038/leu.2009.61 |
Published version: | http://dx.doi.org/10.1038/leu.2009.61 |
Appears in Collections: | Aurora harvest Pathology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.