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Type: Journal article
Title: Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis
Author: Fitzsimmons, T.
Sanders, A.
Bartold, P.
Slade, G.
Citation: Journal of Clinical Periodontology, 2010; 37(1):30-36
Publisher: Blackwell Munksgaard
Issue Date: 2010
ISSN: 0303-6979
Statement of
Tracy R. Fitzsimmons, Anne E. Sanders, P. Mark Bartold and Gary D. Slade
Abstract: AIM: To determine the independent and combined associations of interleukin-1beta (IL-1beta) and C-reactive protein (CRP) in gingival crevicular fluid (GCF) on periodontitis case status in the Australian population. MATERIALS AND METHODS: GCF was collected from 939 subjects selected from the 2004-2006 Australian National Survey of Adult Oral Health: 430 cases had examiner-diagnosed periodontitis, and 509 controls did not. IL-1beta and CRP in GCF were detected by enzyme-linked immunosorbent assays. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated in bivariate and stratified analysis and fully adjusted ORs were estimated using multivariate logistic regression. RESULTS: Greater odds of having periodontitis was associated with higher amounts of IL-1beta (OR=2.4, 95% CI=1.7-3.4 for highest tertile of IL-1beta relative to lowest tertile) and CRP (OR=1.9, 95% CI=1.5-2.5 for detectable CRP relative to undetectable CRP). In stratified analysis, there was no significant interaction between biomarkers (p=0.68). In the multivariate analyses that controlled for conventional periodontal risk factors, these relationships remained (IL-1beta OR=1.8, 95% CI=1.1-2.6; CRP OR=1.7, 95% CI=1.3-2.3). CONCLUSIONS: Elevated odds of clinical periodontitis was associated independently with each biomarker. This suggests that people with elevated biomarkers indicative of either local (IL-1beta) or systemic (CRP) inflammation are more likely to suffer from periodontal disease.
Keywords: C-reactive protein; gingival crevicular fluid; interleukin-1β; periodontitis
Rights: © 2009 University of Adelaide
RMID: 0020100022
DOI: 10.1111/j.1600-051X.2009.01506.x
Appears in Collections:Dentistry publications

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