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dc.contributor.authorSaeed, P.en
dc.contributor.authorBlank, L.en
dc.contributor.authorSelva-Nayagam, D.en
dc.contributor.authorWolbers, J.en
dc.contributor.authorNowak, P.en
dc.contributor.authorGeskus, R.en
dc.contributor.authorWeis, E.en
dc.contributor.authorMourits, M.en
dc.contributor.authorRootman, J.en
dc.identifier.citationBritish Journal of Ophthalmology, 2010; 94(5):564-568en
dc.description.abstractBackground/aims: To report the outcome of primary radiotherapy in patients with progressive optic nerve sheath meningioma (ONSM). Methods: The clinical records of all patients were reviewed in a retrospective, observational, multicentre study. Results: Thirty-four consecutive patients were included. Twenty-six women and eight men received conventional or stereotactic fractionated radiotherapy, and were followed for a median 58 (range 51–156) months. Fourteen eyes (41%) showed improved visual acuity of at least two lines on the Snellen chart. In 17 (50%) eyes, the vision stabilised, while deterioration was noted in three eyes (9%). The visual outcome was not associated with age at the time of radiotherapy (p=0.83), sex (p=0.43), visual acuity at the time of presentation (p=0.22) or type of radiotherapy (p=0.35). Optic disc swelling was associated with improved visual acuity (p<0.01) and 4/11 patients with optic atrophy also showed improvement. Long-term complications were dry eyes in five patients, cataracts in three, and mild radiation retinopathy in four. Conclusion: Primary radiotherapy for patients with ONSM is associated with long-term improvement of visual acuity and few adverse effects.en
dc.description.statementofresponsibilityPeerooz Saeed, Leo Blank, Dinesh Selva, John G. Wolbers, Peter J.C.M. Nowak, Ronald B. Geskus, Ezekiel Weis, Maarten P. Mourits, Jack Rootmanen
dc.publisherBritish Med Journal Publ Groupen
dc.rightsCopyright © The Authorsen
dc.subjectHumans; Meningioma; Optic Nerve Neoplasms; Vision Disorders; Dry Eye Syndromes; Retinal Diseases; Radiation Injuries; Disease Progression; Prognosis; Treatment Outcome; Retrospective Studies; Follow-Up Studies; Sex Distribution; Visual Acuity; Visual Fields; Adolescent; Adult; Aged; Middle Aged; Child; Female; Maleen
dc.titlePrimary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up studyen
dc.typeJournal articleen
pubs.library.collectionOpthalmology & Visual Sciences publicationsen
dc.identifier.orcidSelva-Nayagam, D. [0000-0002-2169-5417]en
Appears in Collections:Opthalmology & Visual Sciences publications

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