Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/61834
Type: | Journal article |
Title: | Warfarin Indications, risks and drug interactions |
Author: | Tadros, R. Shakib, S. |
Citation: | Australian Family Physician, 2010; 39(7):476-479 |
Publisher: | Royal Australian College of General Practitioners |
Issue Date: | 2010 |
ISSN: | 0300-8495 |
Statement of Responsibility: | Rami Tadros and Sepehr Shakib |
Abstract: | Background: Warfarin is a commonly used medication for the prevention and treatment of venous thromboembolism. It can be challenging for both the patient and the prescriber to manage at times. Objective: To describe the mechanism of action of warfarin, and to discuss the indications for warfarinisation, the risks associated with warfarin use, and some of its drug interactions. Discussion: The common indications for warfarinisation are atrial fibrillation, venous thromboembolism and prosthetic heart valves. Contraindications include absolute and relative contraindications, and an individualised risk-benefit analyses is required for each patient. There are many interactions with warfarin, including pharmacokinetic and pharmacodynamic. Pharmacokinetic interactions can be monitored by using International Normalised Ratio levels. Pharmacodynamic interactions require knowledge by the prescriber to predict any interactions with warfarin, and International Normalised Ratio monitoring assists. |
Keywords: | warfarin International Normalised Ratio atrial fibrillation venous thromboembolism heart valve prosthesis |
Rights: | Copyright status unknown |
Published version: | http://www.racgp.org.au/afp/201007/38336 |
Appears in Collections: | Aurora harvest Pharmacology publications |
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