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https://hdl.handle.net/2440/61987
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Type: | Journal article |
Title: | Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972 |
Author: | Thompson, M. Totsika, M. Schembri, M. Mills, P. Seton, E. Trott, D. |
Citation: | Veterinary Microbiology, 2011; 147(1-2):205-208 |
Publisher: | Elsevier Science BV |
Issue Date: | 2011 |
ISSN: | 0378-1135 1873-2542 |
Statement of Responsibility: | Mary F. Thompson, Makrina Totsika, Mark A. Schembri, Paul C. Mills, Erica J. Seton, Darren J. Trott |
Abstract: | Establishment of asymptomatic bacteriuria (ABU) with Escherichia coli 83972 is a viable prophylactic alternative to antibiotic therapy for the prevention of recurrent bacterial urinary tract infection in humans. Approximately 2 × 10(8) viable E. coli 83972 cells were introduced into the bladder of six healthy female dogs via a sterile urinary catheter. The presence of pyuria, depression, stranguria, pollakiuria and haematuria was documented for 6 weeks and urinalysis and aerobic bacterial cultures were performed every 24-72 h. Pyuria was present in all dogs on day 1 post-inoculation and 4/6 dogs (67%) had a positive urine culture on this day. Duration of colonization ranged from 0 to 10 days (median 4 days). Four dogs were re-inoculated on day 20. Duration of colonization following the second inoculation ranged from 1 to 3 days. No dog suffered pyrexia or appeared systemically unwell but all dogs initially exhibited mild pollakiuria and a small number displayed gross haematuria and/or stranguria. By day 3 of each trial all clinical signs had resolved. Persistent bacteriuria was not achieved in any dog but two dogs were colonized for 10 days following a single inoculation. Further research is required to determine whether establishment of ABU in dogs with recurrent urinary tract infection is a viable alternative to repeated doses of antimicrobial agents. |
Keywords: | Urinary tract infection Bacteriuria Canine Bacterial interference Colonization |
Rights: | Crown copyright © 2010 Published by Elsevier B.V. |
DOI: | 10.1016/j.vetmic.2010.06.007 |
Published version: | http://dx.doi.org/10.1016/j.vetmic.2010.06.007 |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 5 |
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