Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/62199
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dc.contributor.authorEarl, R.en
dc.contributor.authorCrowther, C.en
dc.contributor.authorMiddleton, P.en
dc.date.issued2010en
dc.identifier.citationThe Cochrane Database of Systematic Reviews, 2010; 2010(9):1-10en
dc.identifier.issn1469-493Xen
dc.identifier.issn1469-493Xen
dc.identifier.urihttp://hdl.handle.net/2440/62199-
dc.description.abstractBackground: Women with hyperthyroidism in pregnancy have increased risks of miscarriage, stillbirth, preterm birth, and intrauterine growth restriction; and they can develop severe pre-eclampsia or placental abruption. Objective: To assess the effects of interventions for preventing or treating hyperthyroidism in pregnant women. Search strategy: We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (28 July 2010). Selection criteria We intended to include randomised controlled trials comparing antithyroid treatments in pregnant women with hyperthyroidism. Data collection and analysis: Two review authors would have assessed trial eligibility and risk of bias, and extracted data. Main results: No trials were located. Authors’ conclusions: As we did not identify any eligible trials, we are unable to comment on implications for practice, although early identification of hyperthyroidism before pregnancy may allow a woman to choose radioactive iodine therapy or surgery before planning to have a child. Designing and conducting a trial of antithyroid drugs for pregnant women with hyperthyroidism presents formidable challenges. Not only is hyperthyroidism a relatively rare condition, both of the two main drugs used have potential for harm, one for the mother and the other for the child.More observational research is required about the potential harms of methimazole in early pregnancy and about the potential liver damage from propylthiouracil.en
dc.description.statementofresponsibilityRachel Earl, Caroline A Crowther and Philippa Middletonen
dc.language.isoenen
dc.publisherUpdate Software Ltden
dc.rights© 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.en
dc.subjectHumans; Pregnancy Complications; Hyperthyroidism; Pregnancy; Female; Randomized Controlled Trials as Topicen
dc.titleInterventions for preventing and treating hyperthyroidism in pregnancyen
dc.typeJournal articleen
dc.identifier.rmid0020100878en
dc.identifier.doi10.1002/14651858.CD008633.pub2en
dc.identifier.pubid33298-
pubs.library.collectionPaediatrics publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCrowther, C. [0000-0002-9079-4451]en
dc.identifier.orcidMiddleton, P. [0000-0002-8573-338X]en
Appears in Collections:Paediatrics publications

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