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https://hdl.handle.net/2440/63001
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dc.contributor.author | Furuya, Y. | - |
dc.contributor.author | Regner, M. | - |
dc.contributor.author | Lobigs, M. | - |
dc.contributor.author | Koskinen, A. | - |
dc.contributor.author | Mullbacher, A. | - |
dc.contributor.author | Alsharifi, M. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Journal of General Virology, 2010; 91(6):1450-1460 | - |
dc.identifier.issn | 0022-1317 | - |
dc.identifier.issn | 1465-2099 | - |
dc.identifier.uri | http://hdl.handle.net/2440/63001 | - |
dc.description.abstract | We have recently shown that intranasal (i.n.) administration of {gamma}-irradiated A/PR/8 [A/Puerto Rico/8/34 (H1N1)] protects mice against lethal avian influenza A/Vietnam/1203/2004 (H5N1) and other heterosubtypic influenza A infections. Here, we used {gamma}-irradiated, formalin- and UV-inactivated A/PC [A/Port Chalmers/1/73 (H3N2)] virus preparations and compared their ability to induce both homologous and heterosubtypic protective immunity. Our data show that, in contrast to i.n. vaccination with formalin- or UV-inactivated virus, or the present commercially available trivalent influenza vaccine, a single dose of {gamma}-ray-inactivated A/PC ({gamma}-A/PC) conferred significant protection in mice against both homologous and heterosubtypic virus challenges. A multiple immunization regime was required for formalin-inactivated virus preparations to induce protective immunity against a homotypic virus challenge, but did not induce influenza A strain cross-protective immunity. The highly immunogenic {gamma}-A/PC, but not formalin- or UV-inactivated A/PC, nor the currently available subvirion vaccine, elicited cytotoxic T-cell responses that are most likely responsible for the cross-protective and long-lasting immunity against highly lethal influenza A infections in mice. Finally, freeze-drying of {gamma}-A/PC did not affect the ability to induce cross-protective immunity. | - |
dc.description.statementofresponsibility | Yoichi Furuya, Matthias Regner, Mario Lobigs, Aulikki Koskinen, Arno Müllbacher and Mohammed Alsharifi | - |
dc.language.iso | en | - |
dc.publisher | Soc General Microbiology | - |
dc.rights | © 2010 SGM | - |
dc.source.uri | http://dx.doi.org/10.1099/vir.0.018168-0 | - |
dc.subject | Lung | - |
dc.subject | T-Lymphocytes, Cytotoxic | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred BALB C | - |
dc.subject | Mice | - |
dc.subject | Orthomyxoviridae Infections | - |
dc.subject | Body Weight | - |
dc.subject | Formaldehyde | - |
dc.subject | Vaccines, Inactivated | - |
dc.subject | Influenza Vaccines | - |
dc.subject | Viral Load | - |
dc.subject | Virus Inactivation | - |
dc.subject | Survival Analysis | - |
dc.subject | Ultraviolet Rays | - |
dc.subject | Gamma Rays | - |
dc.subject | Female | - |
dc.subject | Influenza A Virus, H3N2 Subtype | - |
dc.subject | Cross Protection | - |
dc.title | Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparations | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1099/vir.0.018168-0 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 5 Microbiology and Immunology publications |
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