Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/63118
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Escherichia coli subtilase cytotoxin |
Author: | Paton, A. Paton, J. |
Citation: | Toxins, 2010; 2(2):215-228 |
Publisher: | MDPI |
Issue Date: | 2010 |
ISSN: | 2072-6651 2072-6651 |
Statement of Responsibility: | Adrienne W. Paton and James C. Paton |
Abstract: | Subtilase cytotoxin (SubAB) is the prototype of a new AB5 toxin family produced by a subset of Shiga toxigenic Escherichia coli (STEC) strains. Its A subunit is a subtilase-like serine protease and cytotoxicity for eukaryotic cells is due to a highly specific, single-site cleavage of BiP/GRP78, an essential Hsp70 family chaperone located in the endoplasmic reticulum (ER). This cleavage triggers a severe and unresolved ER stress response, ultimately triggering apoptosis. The B subunit has specificity for glycans terminating in the sialic acid N-glycolylneuraminic acid. Although its actual role in human disease pathogenesis is yet to be established, SubAB is lethal for mice and induces pathological features overlapping those seen in the haemolytic uraemic syndrome, a lifethreatening complication of STEC infection. The toxin is also proving to be a useful tool for probing the role of BiP and ER stress in a variety of cellular functions. |
Keywords: | subtilase cytotoxin AB5 toxin BiP/GRP78 endoplasmic reticulum stress Shiga toxigenic Escherichia coli |
Rights: | © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
DOI: | 10.3390/toxins2020215 |
Published version: | http://dx.doi.org/10.3390/toxins2020215 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_63118.pdf | Published version | 182.26 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.