Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/63384
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Type: Journal article
Title: C-reactive protein in gingival crevicular fluid may be indicative of systemic inflammation
Author: Megson, E.
Fitzsimmons, T.
Dharmapatni, A.
Bartold, P.
Citation: Journal of Clinical Periodontology, 2010; 37(9):797-804
Publisher: Blackwell Munksgaard
Issue Date: 2010
ISSN: 0303-6979
1600-051X
Statement of
Responsibility: 
Emma Megson, Tracy Fitzsimmons, Kencana Dharmapatni and P. Mark Bartold
Abstract: Background and Aim: Periodontitis is associated with elevated C-reactive protein (CRP) in both serum and gingival crevicular fluid (GCF). Although the liver is the primary source of CRP, extra-hepatic production of CRP has been reported. This study aimed to determine whether CRP in GCF is produced locally in the gingivae. Materials and Methods: Gingivae and GCF were collected from non-periodontitis and periodontitis sites. Presence of CRP in gingivae was assessed by immunohistochemistry. CRP in GCF was measured using ELISA. Gene expression for CRP in gingivae was determined using real-time polymerase chain reaction. Results: CRP was found in both the gingivae and GCF. No gingivae had detectable amounts of CRP mRNA. Not all patients with periodontitis had detectable levels of CRP in the GCF. Some non-periodontitis patients had detectable levels of CRP in the GCF. Conclusion: CRP in the GCF appears to be of systemic origin, and therefore may be indicative of systemic inflammation from either a periodontal infection or inflammatory disease elsewhere. The correlation between levels of CRP in GCF and serum requires validation in future studies.
Keywords: C-reactive protein; inflammation; gingival crevicular fluid
Rights: Copyright 2010 John Wiley & Sons A/S
RMID: 0020102842
DOI: 10.1111/j.1600-051X.2010.01603.x
Appears in Collections:Dentistry publications

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