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|Scopus||Web of Science®||Altmetric|
|Title:||Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology|
|Citation:||Fertility and Sterility, 2011; 95(5):1700-1704|
|Publisher:||Elsevier Science Inc|
|Hassan W. Bakos, Richard C. Henshaw, Megan Mitchell and Michelle Lane|
|Abstract:||OBJECTIVE: To determine the relationship between paternal body mass index (BMI), embryo development and pregnancy, and live birth outcomes after assisted reproductive technology (ART). DESIGN: Retrospective analysis of ART cycles. SETTING: Major assisted reproduction center. PATIENT(S): Three hundred five couples undergoing ART in a private fertility clinic. INTERVENTION(S): No intervention was undertaken in patients involved in this study. MAIN OUTCOME MEASURE(S): Live birth outcomes and clinical pregnancy rates. RESULT(S): No significant relationship between paternal BMI and early embryo development was found. However, increased paternal BMI was associated with decreased blastocyst development, clinical pregnancy rates and live birth outcomes. CONCLUSION(S): To our knowledge, this is the first report linking increased paternal BMI and clinical pregnancy and live birth rates after ART treatment. Further work to elucidate the mechanisms involved is required.|
|Keywords:||Sperm; embryo; pregnancy; obesity; male fertility|
|Rights:||Copyright ©2011 American Society for Reproductive Medicine|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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