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Type: Journal article
Title: Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology
Author: Bakos, H.
Henshaw, R.
Mitchell, M.
Lane, M.
Citation: Fertility and Sterility, 2011; 95(5):1700-1704
Publisher: Elsevier Science Inc
Issue Date: 2011
ISSN: 0015-0282
Statement of
Hassan W. Bakos, Richard C. Henshaw, Megan Mitchell and Michelle Lane
Abstract: OBJECTIVE: To determine the relationship between paternal body mass index (BMI), embryo development and pregnancy, and live birth outcomes after assisted reproductive technology (ART). DESIGN: Retrospective analysis of ART cycles. SETTING: Major assisted reproduction center. PATIENT(S): Three hundred five couples undergoing ART in a private fertility clinic. INTERVENTION(S): No intervention was undertaken in patients involved in this study. MAIN OUTCOME MEASURE(S): Live birth outcomes and clinical pregnancy rates. RESULT(S): No significant relationship between paternal BMI and early embryo development was found. However, increased paternal BMI was associated with decreased blastocyst development, clinical pregnancy rates and live birth outcomes. CONCLUSION(S): To our knowledge, this is the first report linking increased paternal BMI and clinical pregnancy and live birth rates after ART treatment. Further work to elucidate the mechanisms involved is required.
Keywords: Sperm; embryo; pregnancy; obesity; male fertility
Rights: Copyright ©2011 American Society for Reproductive Medicine
RMID: 0020105112
DOI: 10.1016/j.fertnstert.2010.11.044
Appears in Collections:Obstetrics and Gynaecology publications

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