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Type: Journal article
Title: Genome plasticity in the mouse oocyte and early embryo
Author: Peaston, A.
Knowles, B.
Hutchison, K.
Citation: Biochemical Society Transactions, 2007; 35(3):618-622
Publisher: Portland Press
Issue Date: 2007
ISSN: 0300-5127
Statement of
A. E. Peaston, B. B. Knowles and K. W. Hutchison
Abstract: In dissecting the molecules and molecular mechanisms that control mammalian oocyte-to-embryo transition, we found abundant transcripts representing developmentally regulated ERVs (endogenous retroviruses) in mouse oocyte and two-cell stage embryo cDNA libraries. These retrotransposons can act as alternative promoters and first exons for diverse genes, synchronizing their expression. Heritable genetic change due to replication of these retrotransposons probably occurs specifically in oocytes and early embryos. ERVs are usually epigenetically silenced, through DNA methylation and chromatin-based mechanisms. Their activation and silencing indicates a change in the epigenetic state of the genome. The thousands of endogenous retro-elements in the mouse genome provides potential scope for large-scale co-ordinated epigenetic fluctuations and leads to the hypothesis that differential transposable element expression triggers sequential reprogramming of the embryonic genome during the oocyte-to-embryo transition.
Keywords: DNA methylation; epigenetics; mouse transcript retrotransposon (MT); oocyte-toembryo transition; retrotransposon
Rights: Copyright 2007 Biochemical Society
RMID: 0020109848
DOI: 10.1042/BST0350618
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Appears in Collections:Animal and Veterinary Sciences publications

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