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|Title:||Correlation between pruritus score and grossly visible erythema in dogs|
|Citation:||Veterinary Dermatology, 2010; 21(5):450-455|
|Publisher:||Blackwell Science Ltd|
|Peter Hill, Jan Rybníček and Peri Lau-Gillard|
|Abstract:||The severity of pruritus and the extent and severity of erythema were quantified in 107 dogs presenting with various dermatoses. Pruritus was assessed using a previously validated scale, and erythema was quantified by assessing severity at 72 different body sites. Pruritus scores were either 0, or followed a normal type of distribution, with most dogs having a score in the middle of the range and a few dogs having low or high scores. The median pruritus score was 6.3 ⁄ 10. Erythema scores were heavily skewed towards lower values, with only a few dogs having high scores. The median diffuse erythema score was 6.0 ⁄ 216 and the median score for maculo-papular ⁄ pustular erythema was 0 ⁄ 1080. Pruritus and erythema scores were significantly correlated with a Spearman rank correlation coefficient of 0.4062 (P < 0.001). However, visual assessment of the data representing the two variables revealed that this was not a consistent biological or clinically relevant correlation. Individual dogs could have a high pruritus score with low erythema score or vice versa. This study raises questions about the use of erythema scoring systems as a primary outcome measure in clinical trials, and also about the role of various inflammatory mediators in the pathogenesis of canine pruritus.|
|Keywords:||Animals; Dogs; Erythema; Pruritus; Dog Diseases; Pain Measurement|
|Rights:||Copyright 2010 The Authors. Journal compilation Copyright 2010 ESVD and ACVD|
|Appears in Collections:||Animal and Veterinary Sciences publications|
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