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https://hdl.handle.net/2440/64895
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Type: | Journal article |
Title: | Predisposition for venoconstriction in the equine laminar dermis: implications in equine laminitis |
Author: | Peroni, J. Moore, J. Noschka, E. Grafton, M. Aceves-Avila, M. Lewis, S. Robertson, T. |
Citation: | Journal of Applied Physiology, 2006; 100(3):759-763 |
Publisher: | Amer Physiological Soc |
Issue Date: | 2006 |
ISSN: | 8750-7587 1522-1601 |
Statement of Responsibility: | John F. Peroni, James N. Moore, Erik Noschka, Megan E. Grafton, Maria Aceves-Avila, Stephen J. Lewis, and Tom P. Robertson |
Abstract: | Equine laminitis is a crippling condition associated with a variety of systemic diseases. Although it is apparent that the prodromal stages of laminitis involve microvascular dysfunction, little is known regarding the physiology of this vasculature. The aim of the present study was to determine the relative responses of equine laminar arteries and veins to the vasoconstrictor agonists phenylephrine (1 nM–10 µM), 5-HT (1 nM–10 µM), PGF2α (1 nM–100 µM), and endothelin-1 (1 pM–1 µM). We have determined that laminar veins were more sensitive, with respect to the concentration of agonist required to initiate a contractile response and to achieve EC50, for all agonists tested. EC50 values, for veins and arteries, respectively, were 84 ± 7 vs. 688 ± 42 nM for phenylephrine, 35 ± 6 vs. 224 ± 13 nM for 5-HT, 496 ± 43 nM vs. 3.0 ± 0.6 µM for PGF2α, and 467 ± 38 pM vs. 70.6 ± 6.4 nM for endothelin-1. Moreover, when expressed as a percentage of the response to a depolarizing stimulus (80 mM potassium), the maximal contractile response of laminar veins exceeded that for the laminar arteries for each agonist. These results indicate that there may be a predisposition for venoconstriction within the vasculature of the equine digit. While this physiological predisposition for venoconstriction may be important in the regulation of blood flow during exercise, it also may help to explain why laminitis can result from a variety of pathological systemic conditions. |
Keywords: | equine laminar arteries veins |
Rights: | Copyright © 2006 the American Physiological Society |
DOI: | 10.1152/japplphysiol.00794.2005 |
Published version: | http://jap.physiology.org/content/100/3/759 |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 5 |
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