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Type: Journal article
Title: Overview and recent advances in neuropathology. Part 1: Central nervous system tumours
Author: Robertson, T.
Koszyca, B.
Gonzales, M.
Citation: Pathology, 2011; 43(2):88-92
Publisher: Taylor & Francis
Issue Date: 2011
ISSN: 0031-3025
Statement of
Thomas Robertson, Barbara Koszyca, and Michael Gonzales
Abstract: This review highlights the recent changes to the World Health Organization (WHO) 4th edition of the classification of central nervous system tumours. The mixed glial and neuronal tumour group continues to expand to encompass three new subtypes of glioneuronal tumours. The main diagnostic points differentiating these tumours are covered. Also covered is an update on issues relating to grading of astrocytic, oligodendroglial and pineal tumours and the recent molecular subtypes observed in medulloblastomas. The theme of molecular genetics is continued in the following section where the four subtypes in the molecular subclassification of glioblastoma; classical, mesenchymal, proneural and neural are outlined. The genetic profile of these subtypes is highlighted as is their varying biological responses to adjuvant therapies. The relationship between chromosome 1p and 19q deletions and treatment responsive oligodendrogliomas is discussed, as are the newer advances relating to silencing of the MGMT gene in astrocytomas and mutations in the IDH-1 gene in both astrocytomas and oligodendrogliomas. The final section in this article provides an update on the concept of glioma stem cells.
Keywords: Brain cancer propagating cells; central nervous system; glial tumours; glioblastoma; glioma stem cells; glioneuronal tumours; IDH-1 gene; medulloblastoma; MGMT gene; molecular genetics; neuropathology; oligodendroglial tumours; pineal parenchymal tumours; WHO classification of tumours
Rights: © 2011 Royal College of Pathologists of Australasia
RMID: 0020102759
DOI: 10.1097/PAT.0b013e3283426e86
Appears in Collections:Pathology publications

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