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https://hdl.handle.net/2440/65749
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Type: | Journal article |
Title: | In the beginning: Generating neural crest cell diversity |
Author: | Ruhrberg, C. Schwarz, Q. |
Citation: | Cell Adhesion and Migration, 2010; 4(4):622-630 |
Publisher: | Landes Bioscience |
Issue Date: | 2010 |
ISSN: | 1933-6918 1933-6926 |
Statement of Responsibility: | Christiana Ruhrberg and Quenten Schwarz |
Abstract: | Neural crest cells (NCCs) are migratory cells that delaminate from the neural tube early in development and then disseminate throughout the embryo to give rise to a wide variety of cell types that are key to the vertebrate body plan. During their journey from the neural tube to their peripheral targets, NCCs progressively differentiate, raising the question when the fate of an individual NCC is sealed. One hypothesis suggests that the fate of a NCC is specified by target-derived signals emanating from the environment they migrate through, while another hypothesis proposes that NCCs are already specified to differentiate along select lineages at the time they are born in the neural tube, with environmental signals helping them to realize their prespecified fate potential. Alternatively, both mechanisms may cooperate to drive NCC diversity. This review highlights recent advances in our understanding of prespecification during trunk NCC development. |
Keywords: | neural crest cell multipotent prespecification neuropilin semaphorin migration cell fate |
Rights: | © 2010 Landes Bioscience |
DOI: | 10.4161/cam.4.4.13502 |
Published version: | http://dx.doi.org/10.4161/cam.4.4.13502 |
Appears in Collections: | Aurora harvest Microbiology and Immunology publications |
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