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https://hdl.handle.net/2440/65787
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Type: | Journal article |
Title: | Regulation of sphingosine kinase and sphingolipid signaling |
Author: | Pitson, S. |
Citation: | Trends in Biochemical Sciences, 2011; 36(2):97-107 |
Publisher: | Elsevier Science London |
Issue Date: | 2011 |
ISSN: | 0968-0004 1362-4326 |
Statement of Responsibility: | Stuart M. Pitson |
Abstract: | Bioactive sphingolipids, including ceramide, sphingosine and sphingosine 1-phosphate are important regulators of many cellular processes, including cell survival, proliferation, differentiation, migration and immune responses. Although the levels of these bioactive sphingolipids are regulated by complex pathways subject to spatial and temporal control, the sphingosine kinases have emerged as critical central regulators of this system and, as a consequence, they have received substantial recent attention as potential therapeutic targets for cancer and a range of other conditions. Deciphering the molecular mechanisms that regulate both the activity and subcellular localization of these enzymes is vital for understanding the control of bioactive sphingolipid generation and action, and has clear implications for therapeutic strategies targeting these enzymes. |
Keywords: | Cells Animals Humans Isoenzymes Phosphotransferases (Alcohol Group Acceptor) Sphingolipids Signal Transduction |
Rights: | Copyright © 2011 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.tibs.2010.08.001 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/405916/description#description |
Published version: | http://dx.doi.org/10.1016/j.tibs.2010.08.001 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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