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Type: Journal article
Title: Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium
Author: Martens, T.
See, F.
Shuster, M.
Sondermeijer, H.
Hefti, M.
Zannettino, A.
Gronthos, S.
Seki, T.
Itescu, S.
Citation: Nature Clinical Practice Cardiovascular Medicine, 2006; 3(Suppl 1):18-22
Publisher: Nature Publishing Group
Issue Date: 2006
ISSN: 1743-4297
Statement of
Timothy P Martens, Fiona See, Michael D Schuster, Hugo P Sondermeijer, Marco M Hefti, Andrew Zannettino, Stan Gronthos, Tetsunori Seki and Silviu Itescu
Abstract: Mesenchymal lineage precursors can be reproducibly isolated from adult mammalian bone marrow and grown in culture. Immunoselection with monoclonal antibodies against STRO-1 and vascular-cell-adhesion molecule 1 (VCAM1/CD106) prior to expansion results in a 1,000-fold enrichment of mesenchymal precursors compared to standard isolation techniques. Intramyocardial injection of human STRO-1-selected precursors in an athymic rat model of acute myocardial infarction results in induction of vascular network formation and arteriogenesis coupled with global functional cardiac recovery.
Keywords: cardiac myogenesis; cardiac neovascularization; mesenchymal precursor cells; STRO-1; VCAM1
Rights: © 2006 Nature Publishing Group
RMID: 0020102289
DOI: 10.1038/ncpcardio0404
Appears in Collections:Medicine publications

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