Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/66147
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Type: Journal article
Title: Glucose absorption and small intestinal transit in critical illness
Author: Deane, A.
Summers, M.
Zaknic, A.
Chapman, M.
Di Bartolomeo, A.
Bellon, M.
Maddox, A.
Russo, A.
Horowitz, M.
Fraser, R.
Citation: Critical Care Medicine, 2011; 39(6):1282-1288
Publisher: Lippincott Williams & Wilkins
Issue Date: 2011
ISSN: 0090-3493
1530-0293
Statement of
Responsibility: 
Adam M. Deane, Matthew J. Summers, Antony V. Zaknic, Marianne J Chapman, Anna E. Di Bartolomeo; Max Bellon, Anne Maddox, Antoinette Russo, Michael Horowitz and Robert J. L. Fraser
Abstract: Objectives: Although enteral nutrition is standard care for critically ill patients, nutrient absorption has not been quantified in this group and may be impaired due to intestinal dysmotility. The objectives of this study were to measure small intestinal glucose absorption and duodenocecal transit and determine their relationship with glycemia in the critically ill. Design: Prospective observational study of healthy and critically ill subjects. Setting: Tertiary mixed medical-surgical adult intensive care unit. Subjects: Twenty-eight critically ill patients and 16 healthy subjects were studied. Materials and Main Results: Liquid feed (100 kcal/100 mL), labeled with Tc-sulfur colloid and including 3 g of 3-O-methylglucose, was infused into the duodenum. Glucose absorption and duodenocecal transit were measured using the area under the 3-O-methylglucose concentration curve and scintigraphy, respectively. Data are median (range). Results and Discussion: Glucose absorption was reduced in critical illness when compared to health (area under the concentration curve: 16 [1–32] vs. 20 [14 –34] mmol/L min; p = .03). Small intestinal transit times were comparable in patients and healthy subjects (192 [9 –240] vs. 168 [6 –240] min; p = .99) and were not related to glucose absorption. Despite higher fasting blood glucose concentrations (6.3 [5.1–9.3] vs. 5.7 [4.6 –7.6] mmol/L; p < .05), the increment in blood glucose was sustained for longer in the critically ill (_ glucose at t = 60; 1.9 [-2.1–5.0] mmol/L vs. -0.2 [-1.3–2.3] mmol/L; p < .01). Conclusions: Critical illness is associated with reduced small intestinal glucose absorption, but despite this, the glycemic response to enteral nutrient is sustained for longer.
Keywords: enteral nutrition; absorption; critical illness; glucose; gastrointestinal motility
Rights: © 2011 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins
RMID: 0020110858
DOI: 10.1097/CCM.0b013e31820ee21f
Appears in Collections:Medicine publications

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