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Type: Journal article
Title: Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain
Author: Grace, P.
Rolan, P.
Hutchinson, M.
Citation: Brain, Behavior, and Immunity, 2011; 25(7):1322-1332
Publisher: Academic Press Inc
Issue Date: 2011
ISSN: 0889-1591
Statement of
Peter M. Grace, Paul E. Rolan and Mark R. Hutchinson
Abstract: Recent evidence implicates an adaptive immune response in the central nervous system (CNS) mechanisms of neuropathic pain. This review identifies how neuropathic pain alters CNS immune privilege to facilitate T cell infiltration. Once in the CNS, T cells may interact with the local antigen presenting cells, microglia, via the major histocompatibility complex and the costimulatory molecules CD40 and B7. In this way, T cells may contribute to the maintenance of neuropathic pain through pro-inflammatory interactions with microglia and by facilitating the activation of astrocytes in the spinal dorsal horn. Based on the evidence presented in this review, we suggest that this bidirectional, pro-inflammatory system of neurons, glia and T cells in neuropathic pain should be renamed the pentapartite synapse, and identifies the latest member as a potential disease-modifying therapeutic target.
Keywords: Allodynia
Central nervous system
Neuropathic pain
T cell
Immunological synapse
Rights: Copyright © 2011 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.bbi.2011.04.003
Appears in Collections:Aurora harvest
Pharmacology publications

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