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|Title:||Genomic characterization of a novel virus found in papillomatous lesions from a southern brown bandicoot (Isoodon obesulus) in Western Australia|
Van Ranst, M.
|Citation:||Virology, 2008; 376(1):173-182|
|Publisher:||Academic Press Inc|
|Mark D. Bennett, Lucy Woolford, Hans Stevens, Marc Van Ranst, Timothy Oldfield, Michael Slaven, Amanda J. O'Hara, Kristin S. Warren, Philip K. Nicholls|
|Abstract:||The genome of a novel virus, tentatively named bandicoot papillomatosis carcinomatosis virus type 2 (BPCV2), obtained from multicentric papillomatous lesions from an adult male southern brown bandicoot (Isoodon obesulus) was sequenced in its entirety. BPCV2 had a circular double-stranded DNA genome consisting of 7277 bp and open reading frames encoding putative L1 and L2 structural proteins and putative large T antigen and small t antigen transforming proteins. These genomic features, intermediate between Papillomaviridae and Polyomaviridae are most similar to BPCV1, recently described from papillomas and carcinomas in the endangered western barred bandicoot (Perameles bougainville). This study also employed in situ hybridization to definitively demonstrate BPCV2 DNA within lesion biopsies. The discovery of BPCV2 provides evidence of virus-host co-speciation between BPCVs and marsupial bandicoots and has important implications for the phylogeny and taxonomy of circular double-stranded DNA viruses infecting vertebrates.|
|Keywords:||Peramelidae; Marsupial; Isoodon obesulus; Virus–host co-speciation; Papillomatosis; Bandicoot papillomatosis carcinomatosis virus type 2; In situ hybridization|
|Rights:||Copyright © 2008 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Animal and Veterinary Sciences publications|
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