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|Title:||Suspected polymyxin B-induced pemphigus vulgaris in a dog|
|Citation:||Veterinary Dermatology, 2007; 18(3):165-170|
|Publisher:||Blackwell Science Ltd|
|Jan Rybníçek and Peter B. Hill|
|Abstract:||A case of pemphigus vulgaris (PV), putatively induced by topical application of polymyxin B ear drops, is described. A 3-year-old, female Tosa Inu, presented with acute onset swelling, blistering and ulceration of the pinnae, nostrils, lips and oral mucous membranes. The dog was depressed, febrile and anorexic. For 7 days prior to the onset of the acute ulcerative disease, polymyxin B ear drops had been applied to both ears to treat an ear infection. Skin and mucosal biopsies showed suprabasilar cleft formation and acantholysis, indicative of PV. The polymyxin B ear drops were discontinued and the dog was treated with intravenous fluids, systemic and topical antibacterial therapy, and immunosuppressive therapy comprising prednisone and azathioprine. Complete remission was noted after 2 weeks, and the immunosuppressive therapy was discontinued one month later. No clinical signs of PV recurred over a 1 year follow-up period. As PV does not usually resolve spontaneously, or enter long-term remission, it was considered that the condition was most likely drug induced due to the aural application of polymyxin B.|
|Keywords:||Ear, External; Animals; Dogs; Pemphigus; Dog Diseases; Polymyxin B; Anti-Bacterial Agents; Diagnosis, Differential; Administration, Cutaneous; Female|
|Rights:||© 2007 The Authors.|
|Appears in Collections:||Animal and Veterinary Sciences publications|
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