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https://hdl.handle.net/2440/66871
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dc.contributor.author | Wu, W. | - |
dc.contributor.author | Cannon, P. | - |
dc.contributor.author | Yan, W. | - |
dc.contributor.author | Tu, Y. | - |
dc.contributor.author | Selva-Nayagam, D. | - |
dc.contributor.author | Qu, J. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Eye, 2011; 25(6):746-753 | - |
dc.identifier.issn | 0950-222X | - |
dc.identifier.issn | 1476-5454 | - |
dc.identifier.uri | http://hdl.handle.net/2440/66871 | - |
dc.description.abstract | Purpose: To investigate the effects of Merogel coverage on ostial patency in endonasal endoscopic dacryocystorhinostomy (EES-DCR) for primary chronic dacryocystitis (PCD). Methods: In all, 260 patients with unilateral PCD were randomized into two groups: the Merogel group and the control group. All patients underwent EES-DCR. The Merogel group received Merogel covering the wound 1–2 mm around the ostium and the control group received no treatment. Patients were followed up for 9 months. The mucosal epithelialization of the wound, the proliferation of fibrosis tissue, and the success rate of ostial patency were compared. Results: Our study included 112 patients in the Merogel group and 115 patients in the control group. At the 2-week review, intact mucosal epithelium lined the ostia in 96 Merogel patients compared with 80 control patients (ITT analysis: χ ²=4.502, P=0.034). At the 9-month review, scars were present in 18 patients in the Merogel group compared with 39 patients in the control group (ITT analysis: χ ²=9.909, P=0.002, ITT analysis). No differences were observed in the granulation formation between the two groups. The success rate of ostial patency reached 94.6% (106/112) in the Merogel group compared with 80% (92/115) in the control group (ITT analysis: χ ²=4.151, P=0.042). Conclusion: Merogel coverage may enhance the success rate of EES-DCR for PCD by promoting mucosal epithelial healing and preventing excessive scarring. | - |
dc.description.statementofresponsibility | W Wu, PS Cannon, W Yan, Y Tu, D Selva and J Qu | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © 2011 Macmillan Publishers Limited. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1038/eye.2011.44 | - |
dc.subject | endonasal endoscopic dacryocystorhinostomy | - |
dc.subject | hyaluronan | - |
dc.subject | ostial patency | - |
dc.subject | mucosa epithelialization | - |
dc.subject | primary chronic dacryocystitis | - |
dc.title | Effects of Merogel coverage on wound healing and ostial patency in endonasal endoscopic dacryocystorhinostomy for primary chronic dacryocystitis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/eye.2011.44 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Selva-Nayagam, D. [0000-0002-2169-5417] | - |
Appears in Collections: | Aurora harvest 5 Opthalmology & Visual Sciences publications |
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