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Type: Journal article
Title: Enamel hypoplasia in the primary dentition of monozygotic and dizygotic twins compared with singleton controls
Author: Taji, S.
Seow, W.
Townsend, G.
Holcombe, T.
Citation: International Journal of Paediatric Dentistry, 2011; 21(3):175-184
Publisher: Blackwell Publishing Ltd.
Issue Date: 2011
ISSN: 0960-7439
Statement of
Sue S. Taji, W. Kim Seow, Grant C. Townsend & Trevor Holcombe
Abstract: <h4>Background</h4>The study of enamel hypoplasia (EH) and opacity in twins provides insights into the contribution of genetic and environmental factors in the expression of enamel defects.<h4>Aim</h4>This study examined prevalence and site concordance of EH and opacity in the primary dentition of 2- to 4-year-old twins and singleton controls to assess the relative contribution of genetics and the environment to the aetiology of these defects.<h4>Design</h4>The study sample consisted of 88 twin children and 40 singletons aged 2-4 years of age. Medical histories were obtained and the children examined for enamel defects.<h4>Results</h4>The prevalence of EH by teeth was 21% in monozygotic twins (MZ), 22% in dizygotic twins (DZ), and 15% in singleton controls. Twins showed a higher prevalence of EH compared with singletons (P < 0.05). Factors contributing to increase EH in twins were neonatal complications including intubation. There were no significant differences in site concordance of EH within the MZ twin pairs compared with DZ twin pairs when only presence of EH was considered, whereas a greater concordance was noted between MZ twin pairs compared with DZ twin pairs when both presence and absence of EH were considered.<h4>Conclusions</h4>The results suggest that both genetic and environmental factors contribute to observed variation of EH, although it is likely that environmental factors exert a greater influence.
Keywords: Tooth, Deciduous
Dental Enamel Hypoplasia
Birth Injuries
Diseases in Twins
Data Interpretation, Statistical
Case-Control Studies
Environmental Exposure
Twins, Dizygotic
Twins, Monozygotic
Socioeconomic Factors
Child, Preschool
Infant, Newborn
Infant, Low Birth Weight
Infant, Premature
Surveys and Questionnaires
Rights: © 2010 The Authors. International Journal of Paediatric Dentistry © 2010 BSPD, IAPD and Blackwell Publishing Ltd.
DOI: 10.1111/j.1365-263X.2010.01106.x
Appears in Collections:Aurora harvest
Dentistry publications

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