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dc.contributor.authorTaji, S.-
dc.contributor.authorSeow, W.-
dc.contributor.authorTownsend, G.-
dc.contributor.authorHolcombe, T.-
dc.identifier.citationInternational Journal of Paediatric Dentistry, 2011; 21(3):175-184-
dc.description.abstract<h4>Background</h4>The study of enamel hypoplasia (EH) and opacity in twins provides insights into the contribution of genetic and environmental factors in the expression of enamel defects.<h4>Aim</h4>This study examined prevalence and site concordance of EH and opacity in the primary dentition of 2- to 4-year-old twins and singleton controls to assess the relative contribution of genetics and the environment to the aetiology of these defects.<h4>Design</h4>The study sample consisted of 88 twin children and 40 singletons aged 2-4 years of age. Medical histories were obtained and the children examined for enamel defects.<h4>Results</h4>The prevalence of EH by teeth was 21% in monozygotic twins (MZ), 22% in dizygotic twins (DZ), and 15% in singleton controls. Twins showed a higher prevalence of EH compared with singletons (P < 0.05). Factors contributing to increase EH in twins were neonatal complications including intubation. There were no significant differences in site concordance of EH within the MZ twin pairs compared with DZ twin pairs when only presence of EH was considered, whereas a greater concordance was noted between MZ twin pairs compared with DZ twin pairs when both presence and absence of EH were considered.<h4>Conclusions</h4>The results suggest that both genetic and environmental factors contribute to observed variation of EH, although it is likely that environmental factors exert a greater influence.-
dc.description.statementofresponsibilitySue S. Taji, W. Kim Seow, Grant C. Townsend & Trevor Holcombe-
dc.publisherBlackwell Publishing Ltd.-
dc.rights© 2010 The Authors. International Journal of Paediatric Dentistry © 2010 BSPD, IAPD and Blackwell Publishing Ltd.-
dc.subjectTooth, Deciduous-
dc.subjectDental Enamel Hypoplasia-
dc.subjectBirth Injuries-
dc.subjectDiseases in Twins-
dc.subjectData Interpretation, Statistical-
dc.subjectCase-Control Studies-
dc.subjectEnvironmental Exposure-
dc.subjectTwins, Dizygotic-
dc.subjectTwins, Monozygotic-
dc.subjectSocioeconomic Factors-
dc.subjectChild, Preschool-
dc.subjectInfant, Newborn-
dc.subjectInfant, Low Birth Weight-
dc.subjectInfant, Premature-
dc.subjectSurveys and Questionnaires-
dc.titleEnamel hypoplasia in the primary dentition of monozygotic and dizygotic twins compared with singleton controls-
dc.typeJournal article-
Appears in Collections:Aurora harvest
Dentistry publications

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