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https://hdl.handle.net/2440/68183
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dc.contributor.author | Ebneter, A. | - |
dc.contributor.author | Chidlow, G. | - |
dc.contributor.author | Wood, J. | - |
dc.contributor.author | Casson, R. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | JAMA Ophthalmology, 2011; 129(10):1337-1344 | - |
dc.identifier.issn | 0003-9950 | - |
dc.identifier.issn | 1538-3601 | - |
dc.identifier.uri | http://hdl.handle.net/2440/68183 | - |
dc.description.abstract | Objective: To evaluate the neuroprotective effect of short-term hyperglycemia on the retinal ganglion cell body and axon in a rat model of experimental glaucoma. Methods: Using a well-described limbal laser technique, unilateral ocular hypertension was induced in 2 groups (26 per group) of Sprague-Dawley rats. One group remained normoglycemic; the other was rendered hyperglycemic by means of an intraperitoneal injection of streptozocin. After 2 weeks of elevated intraocular pressure, axonal and retinal damage profiles were compared using several histological techniques. Immunohistochemical changes in the retina and optic nerve were also assessed. Results: We found convincing evidence of delayed axonal degeneration and retinal ganglion cell death in hyperglycemic rats. Axon loss was reduced by about 50% 2 weeks after induction of ocular hypertension. Survival of retinal ganglion cell perikarya increased to a similar extent in hyperglycemic rats. Conclusions: The optic nerve and retinal ganglion cells are partially protected by short-term hyperglycemia in this rat model of experimental glaucoma. Energy substrate availability may therefore play a role in glaucomatous optic neuropathy. | - |
dc.description.statementofresponsibility | Andreas Ebneter, Glyn Chidlow, John P. M. Wood, Robert J. Casson | - |
dc.language.iso | en | - |
dc.publisher | Amer Medical Assoc | - |
dc.rights | ©2011 American Medical Association. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1001/archophthalmol.2011.269 | - |
dc.subject | Axons | - |
dc.subject | Retinal Ganglion Cells | - |
dc.subject | Animals | - |
dc.subject | Rats | - |
dc.subject | Rats, Sprague-Dawley | - |
dc.subject | Optic Nerve Diseases | - |
dc.subject | Ocular Hypertension | - |
dc.subject | Diabetes Mellitus, Experimental | - |
dc.subject | Hyperglycemia | - |
dc.subject | Nerve Degeneration | - |
dc.subject | Blood Glucose | - |
dc.subject | Nerve Tissue Proteins | - |
dc.subject | Tonometry, Ocular | - |
dc.subject | Cell Count | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Cell Survival | - |
dc.subject | Intraocular Pressure | - |
dc.subject | Cytoprotection | - |
dc.subject | Biomarkers | - |
dc.title | Protection of retinal ganglion cells and the optic nerve during short-term hyperglycemia in experimental glaucoma | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1001/archophthalmol.2011.269 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/626964 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Chidlow, G. [0000-0001-7371-0239] | - |
dc.identifier.orcid | Casson, R. [0000-0003-2822-4076] | - |
Appears in Collections: | Aurora harvest 5 Opthalmology & Visual Sciences publications |
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