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https://hdl.handle.net/2440/68501
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Type: | Journal article |
Title: | Adjuvant 5-fluorouracil in the treatment of localised ocular surface squamous neoplasia |
Author: | Rudkin, A. Muecke, J. |
Citation: | British Journal of Ophthalmology, 2011; 95(7):947-950 |
Publisher: | British Med Journal Publ Group |
Issue Date: | 2011 |
ISSN: | 0007-1161 1468-2079 |
Statement of Responsibility: | Adam K Rudkin, James S Muecke |
Abstract: | Aim: To report the outcome of treatment of localised non-invasive ocular surface squamous neoplasia (OSSN) where topical 5-fluorouracil (5-FU 1%) is used as an adjuvant to surgical excision. Methods: The study was a prospective non-comparative interventional case series. 55 cases of primary localised OSSN and 10 cases of recurrent localised OSSN were treated with excision, cryotherapy and adjuvant 5-FU 1%. In all cases, irrespective of the involvement of surgical margins, a single cycle of 5-FU 1% was administered, four times a day for 2 weeks continuously. The main outcome measures were (1) recurrence and (2) complications related to adjuvant topical chemotherapy. Individuals were reviewed for a minimum of 12 months. Results: There was a single case of recurrence (1.5%). 57% of patients had short-term complications secondary to 5-FU 1%, most frequently lid toxicity (49%), followed by superficial keratitis, epiphora and corneal epithelial defects. Four patients were unable to complete the course of 5-FU 1% because of local toxicity. Conclusions: The management of localised non-invasive OSSN with adjuvant 5-FU 1% was associated with a low rate of local recurrence. Although 5-FU 1% frequently results in short-term complications, most commonly lid toxicity, a full course is usually tolerated. Serious complications appear uncommon in the treatment of localised disease. |
Keywords: | Humans Neoplasms, Squamous Cell Eye Neoplasms Neoplasm Recurrence, Local Fluorouracil Antineoplastic Agents Treatment Outcome Chemotherapy, Adjuvant Prospective Studies Aged Female Male Vision, Ocular |
DOI: | 10.1136/bjo.2010.186171 |
Published version: | http://dx.doi.org/10.1136/bjo.2010.186171 |
Appears in Collections: | Aurora harvest 5 Opthalmology & Visual Sciences publications |
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