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Type: Journal article
Title: Adjuvant 5-fluorouracil in the treatment of localised ocular surface squamous neoplasia
Author: Rudkin, A.
Muecke, J.
Citation: British Journal of Ophthalmology, 2011; 95(7):947-950
Publisher: British Med Journal Publ Group
Issue Date: 2011
ISSN: 0007-1161
Statement of
Adam K Rudkin, James S Muecke
Abstract: Aim: To report the outcome of treatment of localised non-invasive ocular surface squamous neoplasia (OSSN) where topical 5-fluorouracil (5-FU 1%) is used as an adjuvant to surgical excision. Methods: The study was a prospective non-comparative interventional case series. 55 cases of primary localised OSSN and 10 cases of recurrent localised OSSN were treated with excision, cryotherapy and adjuvant 5-FU 1%. In all cases, irrespective of the involvement of surgical margins, a single cycle of 5-FU 1% was administered, four times a day for 2 weeks continuously. The main outcome measures were (1) recurrence and (2) complications related to adjuvant topical chemotherapy. Individuals were reviewed for a minimum of 12 months. Results: There was a single case of recurrence (1.5%). 57% of patients had short-term complications secondary to 5-FU 1%, most frequently lid toxicity (49%), followed by superficial keratitis, epiphora and corneal epithelial defects. Four patients were unable to complete the course of 5-FU 1% because of local toxicity. Conclusions: The management of localised non-invasive OSSN with adjuvant 5-FU 1% was associated with a low rate of local recurrence. Although 5-FU 1% frequently results in short-term complications, most commonly lid toxicity, a full course is usually tolerated. Serious complications appear uncommon in the treatment of localised disease.
Keywords: Humans; Neoplasms, Squamous Cell; Eye Neoplasms; Neoplasm Recurrence, Local; Fluorouracil; Antineoplastic Agents; Treatment Outcome; Chemotherapy, Adjuvant; Prospective Studies; Aged; Female; Male; Vision, Ocular
RMID: 0020110257
DOI: 10.1136/bjo.2010.186171
Appears in Collections:Opthalmology & Visual Sciences publications

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