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https://hdl.handle.net/2440/69139
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Type: | Journal article |
Title: | The green tea polyphenol (−)-epigallocatechin-3-gallate inhibits amyloid-β evoked fibril formation and neuronal cell death in vitro |
Other Titles: | The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits amyloid-beta evoked fibril formation and neuronal cell death in vitro |
Author: | Harvey, B. Musgrave, I. Ohlsson, K. Fransson, A. Smid, S. |
Citation: | Food Chemistry, 2011; 129(4):1729-1736 |
Publisher: | Elsevier Sci Ltd |
Issue Date: | 2011 |
ISSN: | 0308-8146 1873-7072 |
Statement of Responsibility: | B.S. Harvey, I.F. Musgrave, K.S. Ohlsson, Å. Fransson, S.D. Smid |
Abstract: | Alzheimer’s disease is associated with amyloid-β plaques eliciting neuronal oxidative stress. Many naturally occurring compounds have antioxidant properties, but it is unclear if this alone protects against amyloid-β exposure. This study investigated the protective effects of selected bioactive compounds against amyloid-β and pro-oxidant-evoked neurotoxicity in PC12 cells. Neither resveratrol, (−)-epigallocatechin-3-gallate, cyanidin rutinoside or grape skin extract protected PC12 cells against H2O2 or tert butyl hydroperoxide toxicity. Amyloid-β resulted in a concentration-dependent reduction in PC12 cell viability that was unaffected by resveratrol or cyanidin rutinoside pre-treatment. By contrast, (−)-epigallocatechin-3-gallate and grape skin extract significantly reduced amyloid-β-evoked neurotoxicity (by 40%). Only (−)-epigallocatechin-3-gallate was directly able to inhibit amyloid-β aggregate and fibril formation. These results suggest that (−)-epigallocatechin-3-gallate protects neuronal cells by disrupting amyloid-β fibril formation; bioactive polyphenols which disrupt fibril aggregation may confer additional neuroprotection when compared against antioxidant activity alone. |
Keywords: | Amyloid-β Cyanidin rutinoside (−)-Epigallocatechin-3-gallate Grape skin extract Oxidative stress Polyphenols Resveratrol |
Rights: | Crown copyright © 2011 Published by Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.foodchem.2011.06.040 |
Published version: | http://dx.doi.org/10.1016/j.foodchem.2011.06.040 |
Appears in Collections: | Aurora harvest 5 Pharmacology publications |
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