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https://hdl.handle.net/2440/69143
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Type: | Journal article |
Title: | BCR-ABL transcript dynamics support the hypothesis that leukemic stem cells are reduced during imatinib teatment |
Author: | Stein, A. Bottino, D. Modur, V. Branford, S. Kaeda, J. Goldman, J. Hughes, T. Radich, J. Hochhaus, A. |
Citation: | Clinical Cancer Research, 2011; 17(21):6812-6821 |
Publisher: | Amer Assoc Cancer Research |
Issue Date: | 2011 |
ISSN: | 1078-0432 1557-3265 |
Statement of Responsibility: | Andrew M. Stein, Dean Bottino, Vijay Modur, Susan Branford, Jaspal Kaeda, John M. Goldman, Timothy P. Hughes, Jerald P. Radich, and Andreas Hochhaus |
Abstract: | <h4>Purpose</h4>Imatinib induces a durable response in most patients with Philadelphia chromosome-positive chronic myeloid leukemia, but it is currently unclear whether imatinib reduces the leukemic stem cell (LSC) burden, which may be an important step toward enabling safe discontinuation of therapy. In this article, we use mathematical models of BCR-ABL levels to make inferences on the dynamics of LSCs.<h4>Experimental design</h4>Patients with at least 1 BCR-ABL transcript measurement on imatinib were included (N = 477). Maximum likelihood methods were used to test 3 potential hypotheses of the dynamics of BCR-ABL transcripts on imatinib therapy: (i) monoexponential, in which there is little, if any, decline in BCR-ABL transcripts; (ii) biexponential, in which patients have a rapid initial decrease in BCR-ABL transcripts followed by a more gradual response; and (iii) triexponential, in which patients first exhibit a biphasic decline but then have a third phase when BCR-ABL transcripts increase rapidly.<h4>Results</h4>We found that most patients treated with imatinib exhibit a biphasic decrease in BCR-ABL transcript levels, with a rapid decrease during the first few months of treatment, followed by a more gradual decrease that often continues over many years.<h4>Conclusions</h4>We show that the only hypothesis consistent with current data on progenitor cell turnover and with the long-term, gradual decrease in the BCR-ABL levels seen in most patients is that these patients exhibit a continual, gradual reduction of the LSCs. This observation may explain the ability to discontinue imatinib therapy without relapse in some cases. |
Keywords: | Humans Benzamides Piperazines Pyrimidines Fusion Proteins, bcr-abl RNA, Messenger Antineoplastic Agents Protein Kinase Inhibitors Hematopoiesis Protein-Tyrosine Kinases Neoplastic Stem Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive Real-Time Polymerase Chain Reaction Imatinib Mesylate |
Rights: | ©2011 American Association for Cancer Research. |
DOI: | 10.1158/1078-0432.CCR-11-0396 |
Published version: | http://dx.doi.org/10.1158/1078-0432.ccr-11-0396 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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