Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/70325
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Type: | Journal article |
Title: | Ancestry of the Iban is predominantly Southeast Asian: Genetic evidence from autosomal, mitochondrial, and Y chromosomes |
Author: | Simonson, Tatum S. Xing, Jinchuan Barrett, Robert John Jerah, Edward Loa, Peter Chi Chung Zhang, Yuhua Watkins, W. Scott Witherspoon, David J. Huff, Chad D. Woodward, Scott Mowry, Bryan Jorde, Lynn B. |
Citation: | PLoS ONE, 2011; 6(1):e16338 |
Publisher: | Public Library of Science |
Issue Date: | 2011 |
ISSN: | 1932-6203 |
School/Discipline: | School of Medicine : Medicine |
Statement of Responsibility: | Tatum S. Simonson, Jinchuan Xing, Robert Barrett, Edward Jerah, Peter Loa, Yuhua Zhang, W. Scott Watkins, David J. Witherspoon, Chad D. Huff, Scott Woodward, Bryan Mowry, Lynn B.Jorde |
Abstract: | Humans reached present-day Island Southeast Asia (ISEA) in one of the first major human migrations out of Africa. Population movements in the millennia following this initial settlement are thought to have greatly influenced the genetic makeup of current inhabitants, yet the extent attributed to different events is not clear. Recent studies suggest that southto-north gene flow largely influenced present-day patterns of genetic variation in Southeast Asian populations and that late Pleistocene and early Holocene migrations from Southeast Asia are responsible for a substantial proportion of ISEA ancestry. Archaeological and linguistic evidence suggests that the ancestors of present-day inhabitants came mainly from north-tosouth migrations from Taiwan and throughout ISEA approximately 4,000 years ago. We report a large-scale genetic analysis of human variation in the Iban population from the Malaysian state of Sarawak in northwestern Borneo, located in the center of ISEA. Genome-wide single-nucleotide polymorphism (SNP) markers analyzed here suggest that the Iban exhibit greatest genetic similarity to Indonesian and mainland Southeast Asian populations. The most common non-recombining Y(NRY) and mitochondrial (mt) DNA haplogroups present in the Iban are associated with populations of Southeast Asia. We conclude that migrations from Southeast Asia made a large contribution to Iban ancestry, although evidence of potential gene flow from Taiwan is also seen in uniparentally inherited marker data. |
Description: | Extent: 8p. |
Rights: | Copyright: © 2011 Simonson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0016338 |
Appears in Collections: | Medicine publications |
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