Comparative study on 1D (VP1) region of foot and mouth disease virus (Type A strain) among different isolates: Khorasan Razavi isolate and other Iranian and neighboring countries isolates

Abstract

Foot-and-mouth disease (FMD) is one of the most important virus disease in farm animals. Types O, A and Asia1 FMD virus have been endemic in Iran. In these study, samples from suspected livestock were analyzed by RT-PCR experiment. The number of 702 nucleotides determined at 1D -2B region of type A strain isolated from Khorasan Razavi province sequenced and compared with that of other reported isolates type A from Iran and neighboring countries.The results show that field isolated type A has about 89% similarity with other reported isolates type A from Iran and neighboring countries. Furthermore, this virus shows the most similarity with A/IRN/1/87(Samuel). Phylogenitic analysis revealed that virus was closely related to A22-Iraq/99 and A/IRN/iso/105 that rest in the same lineage. The data showed high similarity between type A viruses involved in the Khorasan Razavi province and A/IRN/87v (vaccine strain); so that it can be concluded that the vaccine can produce prophylactic antibody against this virus.