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https://hdl.handle.net/2440/71356
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Type: | Journal article |
Title: | New β-strand templates constrained by Huisgen cycloaddition |
Other Titles: | New beta-strand templates constrained by Huisgen cycloaddition |
Author: | Pehere, A. Abell, A. |
Citation: | Organic Letters, 2012; 14(5):1330-1333 |
Publisher: | Amer Chemical Soc |
Issue Date: | 2012 |
ISSN: | 1523-7060 1523-7052 |
Statement of Responsibility: | Ashok D. Pehere and Andrew D. Abell |
Abstract: | New peptidic templates constrained into a β-strand geometry by linking acetylene and azide containing P(1) and P(3) residues of a tripeptide by Huisgen cycloaddition are presented. The conformations of the macrocycles are defined by NMR studies and those that best define a β-strand are shown to be potent inhibitors of the protease calpain. The β-strand templates presented and defined here are prepared under optimized conditions that should be suitable for targeting a range of proteases and other applications requiring such a geometry. |
Keywords: | Aldehydes Macrocyclic Compounds Calpain Peptides Protease Inhibitors Protein Structure, Secondary Structure-Activity Relationship Cyclization |
Rights: | Copyright © 2012 American Chemical Society |
DOI: | 10.1021/ol3002199 |
Grant ID: | ARC |
Published version: | http://dx.doi.org/10.1021/ol3002199 |
Appears in Collections: | Aurora harvest IPAS publications |
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