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Type: Book chapter
Title: Expression and function of TRP channels in liver cells
Author: Rychkov, G.
Barritt, G.
Citation: Transient Receptor Potential Channels, 2011 / Islam, M. (ed./s), pp.667-686
Publisher: Springer
Publisher Place: 233 Spring St New York NY 10013
Issue Date: 2011
Series/Report no.: Advances in Experimental Medicine and Biology
ISBN: 9789400702646
Statement of
Grigori Y. Rychkov and Gregory J. Barritt
Abstract: The liver plays a central role in whole body homeostasis by mediating the metabolism of carbohydrates, fats, proteins, drugs and xenobiotic compounds, and bile acid and protein secretion. Hepatocytes together with endothelial cells, Kupffer cells, smooth muscle cells, stellate and oval cells comprise the functioning liver. Many members of the TRP family of proteins are expressed in hepatocytes. However, knowledge of their cellular functions is limited. There is some evidence which suggests the involvement of TRPC1 in volume control, TRPV1 and V4 in cell migration, TRPC6 and TRPM7 in cell proliferation, and TRPPM in lysosomal Ca2+ release. Altered expression of some TRP proteins, including TRPC6, TRPM2 and TRPV1, in tumorigenic cell lines may play roles in the development and progression of hepatocellular carcinoma and metastatic liver cancers. It is likely that future experiments will define important roles for other TRP proteins in the cellular functions of hepatocytes and other cell types of which the liver is composed.
Keywords: Liver; Cell Line; Cell Line, Tumor; Humans; Liver Neoplasms; Calcium; Ion Transport; Transient Receptor Potential Channels
Description: Advances in Experimental Medicine and Biology; v. 704
RMID: 0020108734
DOI: 10.1007/978-94-007-0265-3_35
Appears in Collections:Medical Sciences publications

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