Adelaide Research & Scholarship
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https://hdl.handle.net/2440/7243
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| Type: | Journal article |
| Title: | AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location |
| Author: | Stapleton, D. Woollatt, E. Mitchelhill, K. Nicholl, J. Fernandez, C. Michell, B. Witters, L. Power, D. Sutherland, G. Kemp, B. |
| Citation: | FEBS Letters, 1997; 409(3):452-456 |
| Publisher: | WILEY-BLACKWELL |
| Issue Date: | 1997 |
| ISSN: | 0014-5793 1873-3468 |
| Statement of Responsibility: | Stapleton, David; Woollatt, Erica; Mitchelhill, Ken I; Nicholl, Jillian K; Fernandez, C.Shamala; Michell, Belinda J; Witters, Lee A; Power, David A; Sutherland, Grant R; Kemp, Bruce E |
| Abstract: | The AMP-activated protein kinase (AMPK) consists of catalytic alpha and non-catalytic, beta and gamma (38 kDa) subunits and is responsible for acting as a metabolic sensor for AMP levels. There are multiple genes for each subunit and we find that rat liver AMPK-alpha2 isoform catalytic subunit is associated with beta1 and gamma1 and not with beta2 or gamma2 subunit isoforms. The beta1 and gamma1 isoforms are also subunits of the alpha1 isoform. The sequence of cloned human AMPK-beta1 is 95% identical in amino acid sequence with rat beta1. Human chromosomal localizations were determined for AMPK-alpha1 (5p11-p14), AMPK-beta1 (12q24.1-24.3) and AMPK-gamma1 (12q12-q14), respectively. |
| Keywords: | Liver Chromosomes, Human, Pair 5 Chromosomes, Human, Pair 7 Chromosomes, Human, Pair 12 Animals Humans Rats Multienzyme Complexes Isoenzymes Protein Kinases Chromosome Mapping Metaphase Amino Acid Sequence Multigene Family Molecular Sequence Data Male AMP-Activated Protein Kinases Protein Serine-Threonine Kinases |
| DOI: | 10.1016/S0014-5793(97)00569-3 |
| Published version: | http://dx.doi.org/10.1016/s0014-5793(97)00569-3 |
| Appears in Collections: | Aurora harvest Paediatrics publications |
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