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|Title:||Biotin biosynthesis in Mycobacterium tuberculosis: Physiology, biochemistry and molecular intervention|
|Citation:||Protein & Cell, 2011; 2(9):691-695|
|Publisher:||Gaodeng Jiaoyu Chubanshe|
|Wanisa Salaemae, Al Azhar, Grant W. Booker, Steven W. Polyak|
|Abstract:||Biotin is an important micronutrient that serves as an essential enzyme cofactor. Bacteria obtain biotin either through de novo synthesis or by active uptake from exogenous sources. Mycobacteria are unusual amongst bacteria in that their primary source of biotin is through de novo synthesis. Here we review the importance of biotin biosynthesis in the lifecycle of Mycobacteria. Genetic screens designed to identify key metabolic processes have highlighted a role for the biotin biosynthesis in bacilli growth, infection and survival during the latency phase. These studies help to establish the biotin biosynthetic pathway as a potential drug target for new anti-tuberculosis agents.|
|Keywords:||Cell Membrane; Mycobacterium tuberculosis; Mycobacterium Infections; Biotin; Coenzymes; Carbon-Carbon Ligases; Fatty Acids; Carrier Proteins; Virulence; Molecular Structure; Genes, Bacterial; Genome, Bacterial; Metabolic Networks and Pathways|
|Rights:||© Higher Education Press and Springer-Verlag Berlin Heidelberg 2011|
|Appears in Collections:||Molecular and Biomedical Science publications|
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