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Type: Journal article
Title: Localization of the gene encoding the human heat shock cognate protein, HSP73 to chromosome 11
Author: Tavaria, M.
Gabriele, T.
Anderson, R.
Mirault, M.
Baker, E.
Sutherland, G.
Kola, I.
Citation: Genomics, 1995; 29(1):266-268
Publisher: Academic Press
Issue Date: 1995
ISSN: 0888-7543
Statement of
Michael Tavaria, Tim Gabriele, Robin L. Anderson, Marc-Edouard Mirault, Elizabeth Baker, Grant Sutherland, Ismail Kola
Abstract: The heat shock cognate protein HSP73 (or HSC70) is a member of the HSP70 multigene family. This protein has several functions, including binding to nascent polypeptides to facilitate correct folding and the uncoating of clathrin-coated vesicles. Analysis of somatic cell hybrids by two-dimensional protein gel electrophoresis revealed the presence of a 73-kDa protein in two hybrids containing human chromosomes 5, 6, 9, and 11 in common. Using Western blot analysis, we demonstrate that this protein is a member of the HSP70 family and, by Southern blot analysis, that the HSP73 gene is located on human chromosome 11. Fluorescence in situ hybridization further localized HSP73 to the region 11q23.3-q25. This region is involved in a number of genetic rearrangements and is associated with several well-characterized tumours.
Keywords: Cell Line; CHO Cells; Hybrid Cells; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 6; Chromosomes, Human, Pair 9; Chromosomes, Human, Pair 11; Animals; Hominidae; Humans; Carrier Proteins; Blotting, Western; Blotting, Southern; In Situ Hybridization, Fluorescence; Chromosome Mapping; Multigene Family; Molecular Weight; Cricetinae; Male; HSP70 Heat-Shock Proteins; HSC70 Heat-Shock Proteins; Hot Temperature
Rights: Copyright © 1995 Academic Press. All rights reserved.
RMID: 0030005628
DOI: 10.1006/geno.1995.1242
Appears in Collections:Paediatrics publications

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