Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73277
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dc.contributor.authorCasson, R.en
dc.contributor.authorChidlow, G.en
dc.contributor.authorWood, J.en
dc.contributor.authorCrowston, J.en
dc.contributor.authorGoldberg, I.en
dc.date.issued2012en
dc.identifier.citationClinical and Experimental Ophthalmology, 2012; 40(4):341-349en
dc.identifier.issn1442-6404en
dc.identifier.issn1442-9071en
dc.identifier.urihttp://hdl.handle.net/2440/73277-
dc.description.abstractGlaucoma is a term describing a group of ocular disorders with multi-factorial etiology united by a clinically characteristic intraocular pressure-associated optic neuropathy. It is not a single entity and is sometimes referred to in the plural as the glaucomas. All forms are potentially progressive and can lead to blindness. The diverse conditions that comprise glaucoma are united by a clinically characteristic optic neuropathy: glaucomatous optic neuropathy (GON). Evidence suggests that the primary site of neurological injury is at the optic nerve head. This fact enables the conditions to be grouped, irrespective of the causal mechanism(s). The term experimental glaucoma implies model resemblance to the human condition. We propose that 'experimental glaucoma' be restricted to animal models with demonstrable features of GON and/or evidence of a primary axonopathy at the optic nerve head. A fundamental inadequacy in this framework is any reference to the pathogenesis of GON, which remains unclear.en
dc.description.statementofresponsibilityRobert J Casson, Glyn Chidlow, John PM Wood, Jonathan G Crowston, and Ivan Goldbergen
dc.language.isoenen
dc.publisherBlackwell Publishing Asiaen
dc.rights© 2012 The Authors.en
dc.subjectglaucoma; glaucomatous field defect; optic nerve.en
dc.titleDefinition of glaucoma: clinical and experimental conceptsen
dc.typeJournal articleen
dc.identifier.rmid0020120241en
dc.identifier.doi10.1111/j.1442-9071.2012.02773.xen
dc.identifier.pubid24091-
pubs.library.collectionOpthalmology & Visual Sciences publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCasson, R. [0000-0003-2822-4076]en
dc.identifier.orcidChidlow, G. [0000-0001-7371-0239]en
Appears in Collections:Opthalmology & Visual Sciences publications

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